Quantitative Trait Loci for Life Span in Drosophila melanogaster: Interactions With Genetic Background and Larval Density

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dc.contributor.authorLeips, Jeff
dc.contributor.authorMackay,  Trudy F C
dc.date.accessioned2023-08-07T22:11:14Z
dc.date.available2023-08-07T22:11:14Z
dc.date.issued2000-08-01
dc.description.abstractThe genetic architecture of variation in adult life span was examined for a population of recombinant inbred lines, each of which had been crossed to both inbred parental strains from which the lines were derived, after emergence from both high and low larval density. QTL affecting life span were mapped within each sex and larval density treatment by linkage to highly polymorphic roo-transposable element markers, using a composite interval mapping method. We detected a total of six QTL affecting life span; the additive effects and degrees of dominance for all were highly sex- and larval environment-specific. There were significant epistatic interactions between five of the life span QTL, the effects of which also differed according to genetic background, sex, and larval density. Five additional QTL were identified that contributed to differences among lines in their sensitivity to variation in larval density. Further fine-scale mapping is necessary to determine whether candidate genes within the regions to which the QTL map are actually responsible for the observed variation in life span.en_US
dc.description.sponsorshipWe thank C. Dilda, T. D'Souza, B. Hackett, S. Heinsohn, F. Lawrence, and R. Anholt for help with the flies. Thanks to M. De Luca, R. Fuller, D. Houle, J. Travis, B. Weir, and Z-B. Zeng for discussion of various aspects of this experiment. We also thank A. Clarke, C. Dilda, L. Horth, and two anonymous reviewers for comments on the manuscript. This work was supported by National Institutes of Health NRSA grant GM18818-03 to J.L., and GM 45146 and GM 45344 to T.F.C.M. This is a publication of the W. M. Keck Program for Behavioral Biology.en_US
dc.description.urihttps://academic.oup.com/genetics/article/155/4/1773/6048137en_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m22ajg-4lbg
dc.identifier.citationJeff Leips , Trudy F C Mackay, Quantitative Trait Loci for Life Span in Drosophila melanogaster: Interactions With Genetic Background and Larval Density, Genetics, Volume 155, Issue 4, 1 August 2000, Pages 1773–1788, https://doi.org/10.1093/genetics/155.4.1773en_US
dc.identifier.urihttps://doi.org/10.1093/genetics/155.4.1773
dc.identifier.urihttp://hdl.handle.net/11603/29117
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en_US
dc.subjectGenetic architectureen_US
dc.subjectRecombinant inbred linesen_US
dc.subjectQTL (Quantitative Trait Loci) mappingen_US
dc.titleQuantitative Trait Loci for Life Span in Drosophila melanogaster: Interactions With Genetic Background and Larval Densityen_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0001-8999-6630en_US

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