Ceramides modulate programmed cell death in plants

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dc.contributor.authorLiang, Hua
dc.contributor.authorYao, Nan
dc.contributor.authorSong, Jong Tae
dc.contributor.authorLuo, Song
dc.contributor.authorLu, Hua
dc.contributor.authorGreenberg, Jean T.
dc.date.accessioned2023-07-19T20:39:44Z
dc.date.available2023-07-19T20:39:44Z
dc.date.issued2003-01-01
dc.description.abstractThe balance between the bioactive sphingolipid ceramide and its phosphorylated derivative has been proposed to modulate the amount of programmed cell death (PCD) in eukaryotes. We characterized the first ceramide kinase (CERK) mutant in any organism. The Arabidopsis CERK mutant, called accelerated cell death 5, accumulates CERK substrates and shows enhanced disease symptoms during pathogen attack and apoptotic-like cell death dependent on defense signaling late in development. ACD5 protein shows high specificity for ceramides in vitro. Strikingly, C2 ceramide induces, whereas its phosphorylated derivative partially blocks, plant PCD, supporting a role for ceramide phosphorylation in modulating cell death in plants.en
dc.description.sponsorshipWe thank Jonathan Fitzgerald, John Celenza, and Glyn Dawson for valuable discussions and advice. We also thank Kasturi Hardura, Daniel Lynch, and Cameron Sullards for comments on the manuscript. This work was supported by a grant from the NIH to J.T.G. We thank the Ohio State Stock Center for BAC clones and the RIKEN Center for cDNA clones. The publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.en
dc.description.urihttps://genesdev.cshlp.org/content/17/21/2636en
dc.format.extent7 pagesen
dc.genrejournal articlesen
dc.identifierdoi:10.13016/m2oixs-b824
dc.identifier.citationLiang, Hua, et al. "Ceramides modulate programmed cell death in plants" GENES & DEVELOPMENT 17 (08 Sept, 2003): 2636-2641. https://doi.org/10.1101/gad.1140503.en
dc.identifier.urihttps://doi.org/10.1101/gad.1140503
dc.identifier.urihttp://hdl.handle.net/11603/28790
dc.language.isoenen
dc.publisherCold Spring Harbor Laboratory Pressen
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en
dc.subjectApoptosisen
dc.subjectsphingolipidsen
dc.subjectArabidopsisen
dc.subjectceramide kinaseen
dc.titleCeramides modulate programmed cell death in plantsen
dc.typeTexten
dcterms.creatorhttps://orcid.org/0000-0002-7496-3200en

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