Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses
| dc.contributor.author | Green, Erin | |
| dc.contributor.author | Mas, Gloria | |
| dc.contributor.author | Young, Nicolas L. | |
| dc.contributor.author | Garcia, Benjamin A. | |
| dc.contributor.author | Gozani, Or | |
| dc.date.accessioned | 2023-01-26T16:14:29Z | |
| dc.date.available | 2023-01-26T16:14:29Z | |
| dc.date.issued | 2012-02-19 | |
| dc.description.abstract | Methylation of histones is central to chromatin regulation, and thus novel mechanisms regulating genome function can be revealed through the discovery of new histone methyl marks. Here, we identify Set5 as the first histone H4 methyltransferase in budding yeast, which monomethylates the important H4 lysine residues 5, 8 and 12. Set5’s enzymatic activity functions together with the global chromatin-modifying complexes COMPASS and NuA4 to regulate cell growth and stress responses. | en_US |
| dc.description.sponsorship | The authors are grateful to Ashby Morrison for critical discussions regarding the work and to members of the Gozani and Chua labs for insight. The authors also acknowledge Sharon Dent (The University of Texas MD Anderson Cancer Center), Scott Briggs (Purdue University) and Martha Cyert (Stanford University) for yeast strains and reagents. This work was supported in part by grants from the NIH to O.G. (R01 GM079641) and to B.A.G (DP2OD007447), and an NSF CAREER award (B.A.G.). G.M. was funded by the Postdoctoral Fellowship from the Ministerio de Ciencia e Innovación (Spain) and E.M.G acknowledges support from the Cancer Biology Program Postdoctoral Fellowship at Stanford University. N.L.Y was supported with an NIH F32 NRSA. O.G. is a recipient of an Ellison Senior Scholar in Aging Award. | en_US |
| dc.description.uri | https://www.nature.com/articles/nsmb.2252 | en_US |
| dc.format.extent | 7 pages | en_US |
| dc.genre | journal articles | en_US |
| dc.genre | postprints | en_US |
| dc.identifier | doi:10.13016/m2wd6e-as8s | |
| dc.identifier.citation | Green, Erin M et al. “Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.” Nature structural & molecular biology vol. 19,3 361-3. 19 Feb. 2012, doi:10.1038/nsmb.2252 | en_US |
| dc.identifier.uri | https://doi.org/10.1038/nsmb.2252 | |
| dc.identifier.uri | http://hdl.handle.net/11603/26716 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Nature | en_US |
| dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
| dc.relation.ispartof | UMBC Biological Sciences Department Collection | |
| dc.rights | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1038/nsmb.2252 | en_US |
| dc.title | Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses | en_US |
| dc.type | Text | en_US |
| dcterms.creator | https://orcid.org/0000-0003-3923-6726 | en_US |