CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo

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dc.contributor.authorTalbott, Jason F.
dc.contributor.authorCao, Qilin
dc.contributor.authorBertram, James
dc.contributor.authorNkansah, Michael
dc.contributor.authorBenton, Richard L.
dc.contributor.authorLavik, Erin
dc.contributor.authorWhittemore, Scott R.
dc.date.accessioned2021-03-19T18:16:41Z
dc.date.available2021-03-19T18:16:41Z
dc.date.issued2006-12-20
dc.description.abstractDelivery of factors capable of promoting oligodendrocyte precursor cell (OPC) survival and differentiation in vivo is an important therapeutic strategy for a variety of pathologies in which demyelination is a component, including multiple sclerosis and spinal cord injury. Ciliary neurotrophic factor (CNTF) is a neuropoietic cytokine that promotes both survival and maturation of a variety of neuronal and glial cell populations, including oligodendrocytes. Present results suggest that, although CNTF has a potent survival and differentiation promoting effect in vitro on OPCs isolated from the adult spinal cord, CNTF administration in vivo is not sufficient to promote oligodendrocyte remyelination in the glial-depleted environment of unilateral ethidium bromide (EB) lesions.en_US
dc.description.sponsorshipThis research was supported by NS38665, RR15576, the Kentucky Spinal Cord and Head Injury Research Trust, Norton Healthcare, and the Commonwealth of Kentucky Research Challenge for Excellence Trust Fund.en_US
dc.description.urihttps://www.sciencedirect.com/science/article/abs/pii/S0014488606006376en_US
dc.format.extent9 pagesen_US
dc.genrejournal articles postprintsen_US
dc.identifierdoi:10.13016/m2hlsy-4zft
dc.identifier.citationJason F. Talbott, Qilin Cao et al., CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo, Exp Neurol. 2007 March ; 204(1): 485–489, DOI: https://doi.org/10.1016/j.expneurol.2006.12.013en_US
dc.identifier.urihttps://doi.org/10.1016/j.expneurol.2006.12.013
dc.identifier.urihttp://hdl.handle.net/11603/21201
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleCNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivoen_US
dc.typeTexten_US

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