Translon: a single term for translated regions
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Świrski, Michał I., Jack A. S. Tierney, M. Mar Albà, et al. “Translon: A Single Term for Translated Regions.” Nature Methods, Nature Publishing Group, September 1, 2025, 1–5. https://doi.org/10.1038/s41592-025-02810-3.
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This work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
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Abstract
During translation, ribosomes synthesize polypeptides using RNA molecules as templates. All cellular proteins are products of translation, and the identification of protein-coding regions is the primary goal of genome annotation. Beyond protein synthesis, translation has long been known to have regulatory functions independent of its products¹,². However, only with the advent of ribosome profiling was the broad scale and complexity of translated regions fully appreciated.