Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof

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dc.contributor.authorNovikov, Mikhail S.
dc.contributor.authorBabkov, Denis A.
dc.contributor.authorParamonova, Maria P.
dc.contributor.authorKhandazhinskaya, Anastasia L.
dc.contributor.authorOzerov, Alexander A.
dc.contributor.authorChizhov, Alexander O.
dc.contributor.authorAndrei, Graciela
dc.contributor.authorSnoeck, Robert
dc.contributor.authorBalzarini, Jan
dc.contributor.authorSeley-Radtke, Katherine
dc.date.accessioned2025-07-30T19:22:44Z
dc.date.issued2013-05-16
dc.description.abstractHCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[ω-(phenoxy)alkyl]uracil derivatives were synthesized and examined for antiviral properties. Compounds 17, 20, 24 and 28 were found to exhibit highly specific and promising inhibitory activity against HCMV replication in HEL cell cultures with EC₅₀ values within 5.5–12μM range. Further studies should be undertaken to elucidate the mechanism of action of these compounds and the structure–activity relationship for the linker region.
dc.description.sponsorshipThis work was supported by grant of Russian Foundation For Basic Research (13-04-01391). The antiviral work was supported by KU Leuven (GOA 10/14). The authors thank Lies Van den Heurck, Anita Camps, Steven Carmans, Leentje Persoons, Frieda De Meyer, Leen Ingels and Lizette van Berckelaer for their help in performing the antiviral and cytostatic assays.
dc.description.urihttps://pmc.ncbi.nlm.nih.gov/articles/PMC7127185/
dc.format.extent7 pages
dc.genrejournal articles
dc.identifierdoi:10.13016/m2yblr-cutu
dc.identifier.citationNovikov, Mikhail S., Denis A. Babkov, Maria P. Paramonova, Anastasia L. Khandazhinskaya, Alexander A. Ozerov, Alexander O. Chizhov, Graciela Andrei, Robert Snoeck, Jan Balzarini, and Katherine L. Seley-Radtke. “Synthesis and Anti-HCMV Activity of 1-[ω-(Phenoxy)Alkyl]Uracil Derivatives and Analogues Thereof.” Bioorganic & Medicinal Chemistry 21, no. 14 (July 15, 2013): 4151–57. https://doi.org/10.1016/j.bmc.2013.05.009.
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2013.05.009
dc.identifier.urihttp://hdl.handle.net/11603/39591
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectUracil derivatives
dc.subjectNucleobase
dc.subjectHCMV
dc.subjectAntiviral
dc.subjectNonnucleoside
dc.titleSynthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-0154-3459

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