T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells

dc.contributor.authorCresiski, Robin H.
dc.contributor.authorChristensen, Sean R.
dc.contributor.authorSweet, Rebecca A.
dc.contributor.authorHershberg, Uri
dc.contributor.authorShlomchik, Mark J.
dc.date.accessioned2024-09-24T09:00:01Z
dc.date.available2024-09-24T09:00:01Z
dc.date.issued2008-08-15
dc.description.abstractOn the lupus-prone MRL-lpr/lpr (MRL-lpr) background, AM14 rheumatoid factor (RF) B cells are activated, differentiate into plasmablasts, and undergo somatic hypermutation outside of follicles. Using multiple strategies to impair T cells, we found that such AM14 B cell activation did not require T cells but could be modulated by them. In vitro, the signaling adaptor MyD88 is required for IgG anti-chromatin to stimulate AM14 B cell proliferation when T cells are absent. However, the roles of Toll-like receptors (TLRs) in AM14 B cell activation in vivo have not been investigated. We found that activation, expansion, and differentiation of AM14 B cells depended on MyD88; however, mice lacking either TLR7 or TLR9 displayed partial defects, indicating complex roles for these receptors. T cell-independent activation of certain autoreactive B cells, which gain stimuli via endogenous TLR ligands instead of T cells, may be the initial step in the generation of canonical autoantibodies.
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S1074761308003233
dc.format.extent26 pages
dc.genrejournal articles
dc.genrepostprints
dc.identifierdoi:10.13016/m2jxrv-raju
dc.identifier.citationHerlands, Robin A., Sean R. Christensen, Rebecca A. Sweet, Uri Hershberg, and Mark J. Shlomchik. “T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells.” Immunity 29, no. 2 (August 15, 2008): 249–60. https://doi.org/10.1016/j.immuni.2008.06.009.
dc.identifier.urihttps://doi.org/10.1016/j.immuni.2008.06.009
dc.identifier.urihttp://hdl.handle.net/11603/36390
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMOLIMMUNO
dc.subjectCELLIMMUNO
dc.titleT Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells
dc.typeText

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