Distribution of Chemoattractants in a Heterogeneous Tissue and its Impact on Cell Cluster Migration

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dc.contributor.authorCooley, Jessica
dc.contributor.authorGeorge, Aaron
dc.contributor.authorMekus, Zachary
dc.contributor.authorSabo, Victoria
dc.contributor.authorStrzegowski, Morgan
dc.contributor.authorPeercy, Bradford E.
dc.contributor.authorStarz-Gaiano, Michelle
dc.date.accessioned2018-09-13T19:56:28Z
dc.date.available2018-09-13T19:56:28Z
dc.date.issued2017
dc.description.abstractCell migration is the process in living organisms by which the body heals and diseases spread, so comprehension of this mechanism is beneficial to understanding its applications. We studied the cluster cell migration in the egg chamber of Drosophila melanogaster, or fruit flies, because it is easy to observe and is relatively simple in that organism. A previous model simulates the cell cluster’s migration using forces to determine movement of many individual cells. We improved and revised this system, creating a geometrically accurate model of the egg chamber and mapping the diffusion of the chemoattractants through that domain using a reaction diffusion system. In addition, the base implementation was updated to more accurately simulate the cell migration process. This model aided us in addressing several uncertainties of cluster cell migration, such as identifying the source and quantity of the chemoattractants, the rate at which they are taken in by other cells in the egg chamber, if at all, and the time needed for them to reach the polar and border cells at the anterior of the chamber that gives the most faithful representation of experimental results.en_US
dc.description.urihttps://userpages.umbc.edu/~gobbert/papers/REU2017Team3.pdfen_US
dc.format.extent18 pagesen_US
dc.genreTechnical Reporten_US
dc.identifierdoi:10.13016/M2TT4FX3T
dc.identifier.citationJessica Cooley, Aaron George, Zachary Mekus, Victoria Sabo, Morgan Strzegowski, Bradford E. Peercy, Michelle Starz-Gaiano, Distribution of Chemoattractants in a Heterogeneous Tissue and its Impact on Cell Cluster Migration REU Site : Interdisciplinary Program in High Performance Computing, 2017en_US
dc.identifier.urihttp://hdl.handle.net/11603/11301
dc.language.isoen_USen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Mathematics Department Collection
dc.relation.ispartofUMBC Biological Sciences Deparment
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofseriesHPCF Technical Report HPCF-2017-13
dc.rightsThis item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please contact the author.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
dc.subjectUMBC High Performance Computing Facility (HPCF)en_US
dc.subjectCell migrationen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectchemoattractantsen_US
dc.titleDistribution of Chemoattractants in a Heterogeneous Tissue and its Impact on Cell Cluster Migrationen_US
dc.typeTexten_US

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