Spatio-Temporal Control of LbL Films for Biomedical Applications: From 2D to 3D
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Monge, Claire, Jorge Almodóvar, Thomas Boudou, and Catherine Picart. “Spatio-Temporal Control of LbL Films for Biomedical Applications: From 2D to 3D.” Advanced Healthcare Materials 4, no. 6 (2015): 811–30. https://doi.org/10.1002/adhm.201400715.
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This is the peer reviewed version of the following article: Monge, Claire, Jorge Almodóvar, Thomas Boudou, and Catherine Picart. “Spatio-Temporal Control of LbL Films for Biomedical Applications: From 2D to 3D.” Advanced Healthcare Materials 4, no. 6 (2015): 811–30. https://doi.org/10.1002/adhm.201400715., which has been published in final form at https://doi.org/10.1002/adhm.201400715. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Abstract
Introduced in the '90s by Prof. Moehwald, Lvov, and Decher, the layer-by-layer (LbL) assembly of polyelectrolytes has become a popular technique to engineer various types of objects such as films, capsules and free standing membranes, with an unprecedented control at the nanometer and micrometer scales. The LbL technique allows to engineer biofunctional surface coatings, which may be dedicated to biomedical applications in vivo but also to fundamental studies and diagnosis in vitro. Initially mostly developed as 2D coatings and hollow capsules, the range of complex objects created by the LbL technique has greatly expanded in the past 10 years. In this Review, the aim is to highlight the recent progress in the field of LbL films for biomedical applications and to discuss the various ways to spatially and temporally control the biochemical and mechanical properties of multilayers. In particular, three major developments of LbL films are discussed: 1) the new methods and templates to engineer LbL films and control cellular processes from adhesion to differentiation, 2) the major ways to achieve temporal control by chemical, biological and physical triggers and, 3) the combinations of LbL technique, cells and scaffolds for repairing 3D tissues, including cardio-vascular devices, bone implants and neuro-prosthetic devices.