Microfibrous extracellular matrix enhances in vitro modeling of the liver hepatocytes by modulating metabolism and integrin expression

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dc.contributor.authorHuang, Tianjiao
dc.contributor.authorJones, Curtis G.
dc.contributor.authorChung, Jay H.
dc.contributor.authorChen, Chengpeng
dc.date.accessioned2020-11-04T17:51:13Z
dc.date.available2020-11-04T17:51:13Z
dc.date.issued2020-01
dc.description.abstract2 Introduction The liver carries out a number of essential functions, including blood detoxification, protein synthesis, regulation of energy balance, and production of other biochemicals to maintain the whole-body homeostasis1. In addition to these physiological functions, the liver is also the main site of drug metabolism, making it vulnerable to drug toxicity; indeed, hepatotoxicity is one of the leading causes for drug failure2. Thus, detecting the potential for hepatotoxicity of a drug at the early stage of drug development/screening will minimize the failure rate and, therefore, the cost of bringing a drug into the market. Therefore, hepatic models are invaluable tools in drug discovery and developmenten
dc.description.sponsorshipThis work was supported by the startup funding of UMBC, and the Intramural Research Program of National Heart Lung and Blood Institute, National Institutes of Health. We thank the NHLBI Biochemistry Core and Dr. Duck-Yeon Lee’s assistance for Mass Spectrometry, and the Keith Porter Imaging Center at UMBC.en
dc.description.urihttps://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.0c01311en
dc.format.extent21 pagesen
dc.genrejournal article preprintsen
dc.identifierdoi:10.13016/m2gngg-t0s9
dc.identifier.citationTianjiao Huang, Curtis G. Jones, Jay H. Chung, and Chengpeng Chen, Microfibrous Extracellular Matrix Changes the Liver Hepatocyte Energy Metabolism via Integrins, ACS Biomaterials Science & Engineering 2020 6 (10), 5849-5856 DOI: 10.1021/acsbiomaterials.0c01311en
dc.identifier.urihttps://doi.org/10.1021/acsbiomaterials.0c01311
dc.identifier.urihttp://hdl.handle.net/11603/20013
dc.language.isoenen
dc.publisherACMen
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemistry & Biochemistry Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsThis document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Biomater. Sci. Eng, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acsbiomaterials.0c01311.
dc.titleMicrofibrous extracellular matrix enhances in vitro modeling of the liver hepatocytes by modulating metabolism and integrin expressionen
dc.typeTexten

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