Chemiluminescent solid lipid nanoparticles (SLN) and interations with intact skin

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dc.contributor.authorBreidenich, Jennifer
dc.contributor.authorPatrone, Julia
dc.contributor.authorKelly, Lisa
dc.contributor.authorBenkoski, Jason
dc.contributor.authorLe, Huong
dc.contributor.authorSample, Jennifer
dc.date.accessioned2019-02-05T16:30:28Z
dc.date.available2019-02-05T16:30:28Z
dc.date.issued2009-08-24
dc.descriptionSPIE NanoScience + Engineering, 2009, San Diego, California, United States
dc.description.abstractWe report the synthesis and characterization of a novel nanoparticle formulation designed for skin penetration for the purpose of skin imaging. Solid lipid nanoparticles (SLNs), a drug delivery vehicle, were used as the matrix for targeted delivery of peroxide-sensitive chemiluminescent compounds to the epidermis. Luminol and oxalate were chosen as the chemiluminescent test systems, and a formulation was determined based upon non-toxic components, lotion-like properties, and longevity / visibility of a chemiluminescent signal. The luminescence lifetime was extended in the lipid formulation in comparison to the chemiluminescent system in solution. When applied to porcine skin, our formulation remained detectable relative to negative and positive controls. Initial MTT toxicity testing using HepG2 cells have indicated that this formulation is relatively non-toxic. This formulation could be used to image native peroxides present in tissue that may be indicative of skin disease.en_US
dc.description.sponsorshipThis work was supported by internal research and development (IRAD) funding by the Science and Technology Business Area of the Johns Hopkins University Applied Physics Laboratory. We would like to acknowledge Dr. Victor McCrary, the Business Area Executive for Science and Technology for his support of this project. We would also like to thank Mike Rooney, Jill La Favors, and Neil Murphy for their analytical support.en_US
dc.description.urihttps://www.spiedigitallibrary.org/conference-proceedings-of-spie/7397/73970L/Chemiluminescent-solid-lipid-nanoparticles-SLN-and-interations-with-intact-skin/10.1117/12.826397.full?SSO=1en_US
dc.format.extent11 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2q5jk-z7s9
dc.identifier.citationJennifer Breidenich, Jennifer Breidenich, Julia Patrone, Julia Patrone, Lisa Kelly, Lisa Kelly, Jason Benkoski, Jason Benkoski, Huong Le, Huong Le, Jennifer Sample, Jennifer Sample, "Chemiluminescent solid lipid nanoparticles (SLN) and interations with intact skin", Proc. SPIE 7397, Biosensing II, 73970L (24 August 2009); doi: 10.1117/12.826397;en_US
dc.identifier.urihttps://doi.org/10.1117/12.826397
dc.identifier.urihttp://hdl.handle.net/11603/12708
dc.language.isoen_USen_US
dc.publisherSPIEen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemistry & Biochemistry Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsOne print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
dc.subjectchemiluminescenten_US
dc.subjectnanoparticlesen_US
dc.subjectintact skinen_US
dc.titleChemiluminescent solid lipid nanoparticles (SLN) and interations with intact skinen_US
dc.typeTexten_US

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