Food supplementation with wheat gluten leads to climbing performance decline in Drosophila melanogaster
| dc.contributor.author | Remy, Naphtali Qely | |
| dc.contributor.author | Guevarra, Justine Anne | |
| dc.contributor.author | Vonhoff, Fernando | |
| dc.date.accessioned | 2022-10-26T14:26:56Z | |
| dc.date.available | 2022-10-26T14:26:56Z | |
| dc.date.issued | 2022-09-23 | |
| dc.description.abstract | Gluten sensitivity is associated with digestive and neurological disorders, correlating with abnormal amino acid levels, innate immune responses, gut dysbiosis and movement incoordination. However, the molecular mechanisms linking dietary gluten and brain function remain incompletely understood. We used Drosophila melanogaster to test the effects of gluten ingestion in locomotion performance. Whereas flies on control food showed decreased climbing performance after five weeks, flies exposed to food supplemented with different gluten concentrations showed a significant locomotion decline after three weeks of treatment. Future studies will determine the mechanisms underlying the observed gluten-dependent phenotypes to establish Drosophila models for gluten sensitivity | en_US |
| dc.description.sponsorship | Stocks obtained from the Bloomington Drosophila Stock Center (NIH P40OD018537) were used in this study. Support to NQR was from the LSAMP Program at UMBC, which is funded through an award from the National Science Foundation (Award #1619676). | en_US |
| dc.description.uri | https://www.micropublication.org/journals/biology/micropub-biology-000642 | en_US |
| dc.format.extent | 9 pages | en_US |
| dc.genre | journal articles | en_US |
| dc.identifier | doi:10.13016/m2t4cn-vkzz | |
| dc.identifier.citation | Remy, NQ; Guevarra, JA; Vonhoff, FJ (2022). Food supplementation with wheat gluten leads to climbing performance decline in Drosophila melanogaster. microPublication Biology. 10.17912/micropub.biology.000642. | en_US |
| dc.identifier.uri | https://doi.org/10.17912/micropub.biology.000642 | |
| dc.identifier.uri | http://hdl.handle.net/11603/26223 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | microPublication | en_US |
| dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
| dc.relation.ispartof | UMBC Biological Sciences Department Collection | |
| dc.relation.ispartof | UMBC Faculty Collection | |
| dc.relation.ispartof | UMBC Student Collection | |
| dc.rights | This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author. | en_US |
| dc.rights | Attribution 4.0 International (CC BY 4.0) | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.title | Food supplementation with wheat gluten leads to climbing performance decline in Drosophila melanogaster | en_US |
| dc.type | Text | en_US |
| dcterms.creator | https://orcid.org/0000-0002-0679-1857 | en_US |