Micafungin-Induced Cell Wall Damage Stimulates Morphological Changes Consistent with Microcycle Conidiation in Aspergillus nidulans

Simple item page
dc.contributor.authorReese, Samantha
dc.contributor.authorChelius, Cynthia
dc.contributor.authorRiekhof, Wayne
dc.contributor.authorMarten, Mark
dc.contributor.authorHarris, Steven D.
dc.date.accessioned2021-07-07T20:06:03Z
dc.date.available2021-07-07T20:06:03Z
dc.date.issued2021-06-29
dc.description.abstractFungal cell wall receptors relay messages about the state of the cell wall to the nucleus through the Cell Wall Integrity Signaling (CWIS) pathway. The ultimate role of the CWIS pathway is to coordinate repair of cell wall damage and to restore normal hyphal growth. Echinocandins such as micafungin represent a class of antifungals that trigger cell wall damage by affecting synthesis of β-glucans. To obtain a better understanding of the dynamics of the CWIS response and its multiple effects, we have coupled dynamic transcriptome analysis with morphological studies of Aspergillus nidulans hyphae in responds to micafungin. Our results reveal that expression of the master regulator of asexual development, BrlA, is induced by micafungin exposure. Further study showed that micafungin elicits morphological changes consistent with microcycle conidiation and that this effect is abolished in the absence of MpkA. Our results suggest that microcycle conidiation may be a general response to cell wall perturbation which in some cases would enable fungi to tolerate or survive otherwise lethal damageen_US
dc.description.sponsorshipThe research conducted in this publication was funded by the NASA Grant (80NSSC17K0737) and by the NSF Grant (MCB 1601935).en_US
dc.description.urihttps://www.mdpi.com/2309-608X/7/7/525en_US
dc.format.extent2 filesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2oj6k-guhz
dc.identifier.citationReese, Samantha et al.; Micafungin-Induced Cell Wall Damage Stimulates Morphological Changes Consistent with Microcycle Conidiation in Aspergillus nidulans; Journal of Fungi, 7(7), 525, 29 June 2021; https://doi.org/10.3390/jof7070525en_US
dc.identifier.urihttps://doi.org/10.3390/jof7070525
dc.identifier.urihttp://hdl.handle.net/11603/21871
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.titleMicafungin-Induced Cell Wall Damage Stimulates Morphological Changes Consistent with Microcycle Conidiation in Aspergillus nidulansen_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0002-1863-8956

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
jof-07-00525-v2.pdf
Size:
1.22 MB
Format:
Adobe Portable Document Format
Description:
Micafungin-Induced Cell Wall Damage Stimulates Morphological Changes Consistent with Microcycle Conidiation in Aspergillus nidulans
Download
No Thumbnail Available
Name:
jof-07-00525-s001.zip
Size:
39.91 MB
Format:
Unknown data format
Description:
Supplementary Material
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.56 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

UMBC Chemical, Biochemical & Environmental Engineering Department
UMBC Faculty Collection