A highly facile approach to the synthesis of novel 2-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-N-phenylacetamides

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dc.contributor.authorNovikov, Mikhail S.
dc.contributor.authorBabkov, Denis A.
dc.contributor.authorParamonova, Maria P.
dc.contributor.authorChizhov, Alexander O.
dc.contributor.authorKhandazhinskaya, Anastasia L.
dc.contributor.authorSeley-Radtke, Katherine
dc.date.accessioned2025-07-30T19:22:45Z
dc.date.issued2012-11-29
dc.description.abstractA series of heterocyclic compounds were designed as potential nonnucleoside HIV reverse transcriptase inhibitors. Although the compounds ultimately proved inactive against HIV, during the course of the synthesis, a new and highly facile method to realize N-phenylacetamides was developed. Notably, the new route avoids the intractable workups and byproducts previously reported procedures have been associated with, thereby making this approach highly attractive to adaptation with other heterocyclics.
dc.description.sponsorshipThis work was supported by the Russian Foundation for Basic Research (Grant 10-04-0056a). The authors would like to thank Professor Jan Balzarini of the Rega Institute for antiviral evaluation of synthesized compounds.
dc.description.urihttps://pmc.ncbi.nlm.nih.gov/articles/PMC7111777/
dc.format.extent3 pages
dc.genrejournal articles
dc.identifierdoi:10.13016/m2b91c-ikc8
dc.identifier.citationNovikov, Mikhail S., Denis A. Babkov, Maria P. Paramonova, Alexander O. Chizhov, Anastasia L. Khandazhinskaya, and Katherine L. Seley-Radtke. “A Highly Facile Approach to the Synthesis of Novel 2-(3-Benzyl-2,4-Dioxo-1,2,3,4-Tetrahydropyrimidin-1-Yl)-N-Phenylacetamides.” Tetrahedron Letters 54, no. 6 (February 6, 2013): 576–78. https://doi.org/10.1016/j.tetlet.2012.11.090.
dc.identifier.urihttps://doi.org/10.1016/j.tetlet.2012.11.090
dc.identifier.urihttp://hdl.handle.net/11603/39594
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectNNRTI
dc.subjectHeteroaromatic
dc.subjectHeterocycles
dc.subjectPyrimidines
dc.titleA highly facile approach to the synthesis of novel 2-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-N-phenylacetamides
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-0154-3459

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