Myeloid Derived-Suppressor Cells: Their role in cancer and obesity

Simple item page
dc.contributor.authorOstrand-Rosenberg, Suzanne
dc.date.accessioned2018-04-23T18:05:07Z
dc.date.available2018-04-23T18:05:07Z
dc.date.issued2018-04
dc.description.abstractMyeloid-derived suppressor cells (MDSC) are present in most individuals with cancer where they inhibit adaptive and innate antitumor immunity and are an obstacle to cancer immunotherapies. Chronic inflammation is characteristic of adipose tissue and is a risk factor for the onset and progression of cancer in obese individuals. Because MDSC accumulate in response to inflammation, it has been hypothesized that one of the mechanisms by which obesity promotes malignancy is through the induction of MDSC. This article reviews the data supporting this hypothesis, the role of leptin and fatty acid metabolism in the induction of MDSC, and the surprising finding that although MDSC promote tumor progression, they are protective against some of the metabolic dysfunction associated with obesity.en_US
dc.format.extent24 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/M2W37KX9W
dc.identifier.citationOstrand-Rosenberg, S., 2018. Myeloid-derived suppressor cells: their role in cancer and obesity. Curr. Opin. Immunol. 51: 68-75.en_US
dc.identifier.urihttps://doi.org/10.1016/j.coi.2018.03.007
dc.identifier.urihttp://hdl.handle.net/11603/8784
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please contact the author.
dc.subjectMyeloid-derived suppressor cells (MDSC)en_US
dc.subjectantitumor immunityen_US
dc.subjectcancer immunotherapiesen_US
dc.subjecttumor growthen_US
dc.subjectobesityen_US
dc.subjectleptinen_US
dc.subjectfatty acid metabolismen_US
dc.titleMyeloid Derived-Suppressor Cells: Their role in cancer and obesityen_US
dc.typeTexten_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
COI 2018 for Michelle at UMBC.pdf
Size:
683.17 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
license.txt
Size:
1.68 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
No Thumbnail Available
Name:
currentopinionsinimmunologylicense.pdf
Size:
67.99 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

UMBC Biological Sciences Department
UMBC Faculty Collection