Myeloid Derived-Suppressor Cells: Their role in cancer and obesity

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dc.contributor.authorOstrand-Rosenberg, Suzanne
dc.date.accessioned2018-04-23T18:05:07Z
dc.date.available2018-04-23T18:05:07Z
dc.date.issued2018-04
dc.description.abstractMyeloid-derived suppressor cells (MDSC) are present in most individuals with cancer where they inhibit adaptive and innate antitumor immunity and are an obstacle to cancer immunotherapies. Chronic inflammation is characteristic of adipose tissue and is a risk factor for the onset and progression of cancer in obese individuals. Because MDSC accumulate in response to inflammation, it has been hypothesized that one of the mechanisms by which obesity promotes malignancy is through the induction of MDSC. This article reviews the data supporting this hypothesis, the role of leptin and fatty acid metabolism in the induction of MDSC, and the surprising finding that although MDSC promote tumor progression, they are protective against some of the metabolic dysfunction associated with obesity.en
dc.format.extent24 pagesen
dc.genrejournal articlesen
dc.identifierdoi:10.13016/M2W37KX9W
dc.identifier.citationOstrand-Rosenberg, S., 2018. Myeloid-derived suppressor cells: their role in cancer and obesity. Curr. Opin. Immunol. 51: 68-75.en
dc.identifier.urihttps://doi.org/10.1016/j.coi.2018.03.007
dc.identifier.urihttp://hdl.handle.net/11603/8784
dc.language.isoenen
dc.publisherElsevieren
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please contact the author.
dc.subjectMyeloid-derived suppressor cells (MDSC)en
dc.subjectantitumor immunityen
dc.subjectcancer immunotherapiesen
dc.subjecttumor growthen
dc.subjectobesityen
dc.subjectleptinen
dc.subjectfatty acid metabolismen
dc.titleMyeloid Derived-Suppressor Cells: Their role in cancer and obesityen
dc.typeTexten

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