Next Steps in Integrative Biology: Mapping Interactive Processes Across Levels of Biological Organization

dc.contributor.authorCavigelli, Sonia
dc.contributor.authorLeips, Jeff
dc.contributor.authorXiang, Qiu-Yun (Jenny)
dc.contributor.authorLemke, Dawn
dc.contributor.authorKonow, Nicolai
dc.date.accessioned2021-08-05T16:10:29Z
dc.date.available2021-08-05T16:10:29Z
dc.date.issued2021-07-14
dc.description.abstractEmergent biological processes result from complex interactions within and across levels of biological organization, ranging from molecular to environmental dynamics. Powerful theories, database tools, and modeling methods have been designed to characterize network connections within levels, such as those among genes, proteins, biochemicals, cells, organisms and species. Here, we propose that developing integrative models of organismal function in complex environments can be facilitated by taking advantage of these methods to identify key nodes of communication across levels of organization. Mapping key drivers or connections among levels of organization will provide data and leverage to model potential rule-sets by which organisms respond and adjust to perturbations at any level of biological organization.en_US
dc.description.sponsorshipWe thank the US National Science Foundation’s “Reintegrating Biology Jumpstart” initiative that brought us together for discussions of the ideas that form the basis for this perspective paper. We are indebted to an anonymous reviewer, who offered sage advice and contributed realworld research examples that bolstered the message of this paper.en_US
dc.description.urihttps://academic.oup.com/icb/advance-article-abstract/doi/10.1093/icb/icab161/6321168?en_US
dc.format.extent17 pagesen_US
dc.genrejournal articlesen_US
dc.genrepostprints
dc.identifierdoi:10.13016/m2cemo-8vpl
dc.identifier.citationCavigelli, Sonia et al.; Next Steps in Integrative Biology: Mapping Interactive Processes Across Levels of Biological Organization; Integrative and Comparative Biology, icab161, 14 July, 2021; https://doi.org/10.1093/icb/icab161en_US
dc.identifier.urihttps://doi.org/10.1093/icb/icab161
dc.identifier.urihttp://hdl.handle.net/11603/22313
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis is a pre-copyedited, author-produced version of an article accepted for publication in Integrative and Comparative Biology following peer review. The version of record Cavigelli, Sonia et al.; Next Steps in Integrative Biology: Mapping Interactive Processes Across Levels of Biological Organization; Integrative and Comparative Biology, icab161, 14 July, 2021; https://doi.org/10.1093/icb/icab161 is available online at: https://academic.oup.com/icb/advance-article-abstract/doi/10.1093/icb/icab161/6321168.
dc.rightsAccess to this item will begin on 2022-07-14
dc.titleNext Steps in Integrative Biology: Mapping Interactive Processes Across Levels of Biological Organizationen_US
dc.typeTexten_US

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