Identification of targets of the heterochronic protein LIN-29 and their implications for the larva-to-adult transition in C. elegans

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dc.contributor.advisorEisenmann, David M
dc.contributor.authorAbete, Patricia
dc.contributor.departmentBiological Sciences
dc.contributor.programBiological Sciences
dc.date.accessioned2021-01-29T18:11:44Z
dc.date.available2021-01-29T18:11:44Z
dc.date.issued2018-01-01
dc.description.abstractThe precise temporal control of gene expression is an essential aspect of metazoan development. The ecdysozan C. elegans goes through six life stages (embryo, L1 to L4, and adult) separated by molts, and analyses of modENCODE data showed that most members of the large cuticle collagen (col) gene family express predominantly at a single stage. This temporal preference motivated us to investigate the mechanisms underlying col gene expression and here we focus on a subset of col genes expressed in the L4 stage. We identified minimal promoter regions of <300 bp for col-38, col-49, and col-63 in which we predicted cis-regulatory sequences and evaluated their function in vivo via mutagenesis of a col-38p
dc.formatapplication:pdf
dc.genredissertations
dc.identifierdoi:10.13016/m2ei0s-sr3s
dc.identifier.other11925
dc.identifier.urihttp://hdl.handle.net/11603/20640
dc.languageen
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Theses and Dissertations Collection
dc.relation.ispartofUMBC Graduate School Collection
dc.relation.ispartofUMBC Student Collection
dc.sourceOriginal File Name: Abete_umbc_0434D_11925.pdf
dc.titleIdentification of targets of the heterochronic protein LIN-29 and their implications for the larva-to-adult transition in C. elegans
dc.typeText
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