The Influence of Stochastic Parameters on Calcium Waves in a Heart Cell

dc.contributor.authorBrewster, Matthew W.
dc.date.accessioned2018-10-26T13:33:56Z
dc.date.available2018-10-26T13:33:56Z
dc.date.issued2013
dc.description.abstractCalcium is a critical component in many cellular functions. It serves many important functions such as signal transduction, contraction of muscles, enzyme function, and maintaining potential difference across excitable membranes. In this study we examine calcium waves in a heart cell and how they diffuse. Calcium sparks are intracellular release events which are important in converting electrical stimuli into mechanical responses. We investigate the effects of a stochastic spatially uniform ux density term as well as of a stochastic spatially varying ux density term. We hypothesize that having a stochastic ux density term is more physiologically accurate. We use an array of statistical techniques as well as parallel computing to facilitate the large number of simulation runs.en_US
dc.description.sponsorshipThe facility is supported by the U.S. National Science Foundation through the MRI program (grant nos. CNS-0821258 and CNS{1228778) and the SCREMS program (grant no. DMS-0821311), with additional substantial support from the University of Maryland, Baltimore County (UMBC).en_US
dc.description.urihttps://userpages.umbc.edu/~gobbert/papers/BrewsterThesis2014.pdfen_US
dc.format.extent20 pagesen_US
dc.genresenior thesisen_US
dc.identifierdoi:10.13016/M2J09W798
dc.identifier.urihttp://hdl.handle.net/11603/11741
dc.language.isoen_USen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Mathematics Department Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectStochastic Parametersen_US
dc.subjectCalcium Wavesen_US
dc.subjectHeart Cellen_US
dc.subjectcontraction of musclesen_US
dc.subjectenzymeen_US
dc.subjectUMBC High Performance Computing Facility (HPCF)en_US
dc.titleThe Influence of Stochastic Parameters on Calcium Waves in a Heart Cellen_US
dc.typeTexten_US

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