Point-of-care biosensor systems for cancer diagnostics/prognostics

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dc.contributor.authorSoper, Steven A.
dc.contributor.authorBrown, Kathlynn
dc.contributor.authorEllington, Andrew
dc.contributor.authorFrazier, Bruno
dc.contributor.authorGarcia-Manero, Guillermo
dc.contributor.authorGau, Vincent
dc.contributor.authorGutman, Steven I.
dc.contributor.authorHayes, Daniel F.
dc.contributor.authorKorte, Brenda
dc.contributor.authorLanders, James L.
dc.contributor.authorLarson, Dale
dc.contributor.authorLigler, Frances
dc.contributor.authorMajumdar, Arun
dc.contributor.authorMascini, Marco
dc.contributor.authorNolte, David
dc.contributor.authorRosenzweig, Zeev
dc.contributor.authorWang, Joseph
dc.contributor.authorWilson, David
dc.date.accessioned2021-04-19T18:40:25Z
dc.date.available2021-04-19T18:40:25Z
dc.date.issued2006-02-13
dc.description.abstractWith the growing number of fatalities resulting from the 100 or so cancer-related diseases, new enabling tools are required to provide extensive molecular profiles of patients to guide the clinician in making viable diagnosis and prognosis. Unfortunately with cancer-related diseases, there is not one molecular marker that can provide sufficient information to assist the clinician in making effective prognoses or even diagnoses. Indeed, large panels of markers must typically be evaluated that cut across several different classes (mutations in certain gene fragments—DNA; over/under-expression of gene activity as monitored by messenger RNAs; the amount of proteins present in serum or circulating tumor cells). The classical biosensor format (dipstick approach for monitoring the presence of a single element) is viewed as a valuable tool in many bioassays, but possesses numerous limitations in cancer due primarily to the single element nature of these sensing platforms. As such, if biosensors are to become valuable tools in the arsenal of the clinician to manage cancer patients, new formats are required. This review seeks to provide an overview of the current thinking on molecular profiling for diagnosis and prognosis of cancers and also, provide insight into the current state-of-the-art in the biosensor field and new strategies that must be considered to bring this important technology into the cancer field.en_US
dc.description.sponsorshipThe authors would like to thank the National Institutes of Health (National Cancer Institute) for supporting the workshop (June 2005, Bethesda, MD) from which this document evolved.en_US
dc.description.urihttps://www.sciencedirect.com/science/article/abs/pii/S0956566306000121?via%3Dihub#!en_US
dc.format.extent11 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2bboy-dnn3
dc.identifier.citationSoper, Steven A.; Brown, Kathlynn; Ellington, Andrew; Frazier, Bruno; Garcia-Manero, Guillermo; Gau, Vincent; Gutman, Steven I.; Hayes, Daniel F.; Korte, Brenda; Landers, James L.; Larson, Dale; Ligler, Frances; Majumdar, Arun; Mascini, Marco; Nolte, David; Rosenzweig, Zeev; Wang, Joseph; Wilson, David; Point-of-care biosensor systems for cancer diagnostics/prognostics; Biosensors and Bioelectronics, Volume 21, Issue 10, 15 April 2006, Pages 1932-1942; https://www.sciencedirect.com/science/article/abs/pii/S0956566306000121?via%3Dihub#!en_US
dc.identifier.urihttps://doi.org/10.1016/j.bios.2006.01.006
dc.identifier.urihttp://hdl.handle.net/11603/21349
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemistry & Biochemistry Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsPublic Domain Mark 1.0*
dc.rightsThis work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
dc.rights.urihttp://creativecommons.org/publicdomain/mark/1.0/*
dc.titlePoint-of-care biosensor systems for cancer diagnostics/prognosticsen_US
dc.typeTexten_US

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