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Item The journey to building a diverse, equitable, and inclusive American Medical Informatics Association(Oxford University Press, 2024-10-11) Bright, Tiffani J.; Bear Don’t Walk IV, Oliver J.; Johnson, Carl Erwin; Petersen, Carolyn; Dykes, Patricia C.; Martin, Krista G.; Johnson, Kevin B.; Walters-Threat, Lois; Craven, Catherine K.; Lucero, Robert J.; Jackson, Gretchen P.; Rizvi, Rubina F.The American Medical Informatics Association (AMIA) Task Force on Diversity, Equity, and Inclusion (DEI) was established to address systemic racism and health disparities in biomedical and health informatics, aligning with AMIA’s mission to transform healthcare. AMIA’s DEI initiatives were spurred by member voices responding to police brutality and COVID-19’s impact on Black/African American communities.The Task Force, consisting of 20 members across 3 groups aligned with AMIA’s 2020-2025 Strategic Plan, met biweekly to develop DEI recommendations with the help of 16 additional volunteers. These recommendations were reviewed, prioritized, and presented to the AMIA Board of Directors for approval.In 9 months, the Task Force (1) created a logic model to support workforce diversity and raise AMIA’s DEI awareness, (2) conducted an environmental scan of other associations’ DEI activities, (3) developed a DEI framework for AMIA meetings, (4) gathered member feedback, (5) cultivated DEI educational resources, (6) created a Board nominations and diversity session, (7) reviewed the Board’s Strategic Planning for DEI alignment, (8) led a program to increase diversity at the 2020 AMIA Virtual Annual Symposium, and (9) standardized socially-assigned race and ethnicity data collection.The Task Force proposed actionable recommendations that focused on AMIA’s role in addressing systemic racism and health equity, helping the organization understand its member diversity.This work supported marginalized groups, broadened the research agenda, and positioned AMIA as a DEI leader while reinforcing the need for ongoing transformation within informatics.Item A REVIEW ON QUALITY BY DESIGN APPROACH (QBD) AND IT’S BENEFITS(International Journal Of Pharmacognosy, 2024-08-31) Krishna, Ambati Vamsi; Mounika, Paradeshi; Sai, G. Vedavathi; Venkatesh, KannedariThe newest approach in pharmaceutical production linked to quality is called Quality by Design (QbD). To guarantee that premium-grade pharmaceuticals are produced, Pharmaceutical Quality by Design, or QbD, is discussed in this article. A description of Quality by Design is provided along with a list of its constituent parts. Every unit activity has its own set of quality metrics and characteristics. The use of Quality by Design and its associated measures can yield significant benefits for pharmaceutical goods. The foundation of pharmaceutical R&D is high-quality drugs and the procedures used in their production. A product’s quality cannot be easily verified because this paper just summarises the product’s quality profile and the most important components of Quality by Design. Quality by design (QbD) and end-product testing are two ways to compare the quality of various goods. Quality by Design is based on the ICH Guidelines. ICH guidelines apply to the development of medications and the application of quality control methods. The research and manufacturing of pharmaceuticals might profit from Quality by Design (QbD). As the product develops and is designed, it is crucial to determine the desired product performance report under these ideas. The TPP, QTPP, and CQA stand for target product profile, quality target product profile, and critical quality characteristics. to identify and regulate sources of changeability and to understand how key material attributes (CAM) and critical process parameters (CPP) of the raw material affect the CQAs. Quality-based drug development (QbD) can provide valuable insights for the design, development, and manufacturing of pharmaceutical products. The present overview discusses the historical context, fundamentals of the QbD methodology, and regulatory requirements. The method’s aim, the experiment’s design, and the risk assessment are all explained in depth for the QbD aspects. The ICH Guidelines provide the basis of Quality by Design. The ICH Guidelines Q8, Q9, and Q10 for pharmaceutical quality systems, quality risk management, and pharmaceutical development, respectively, serve as its foundation. It also provides information on applying Quality by Design to the creation and production of medicines.Item Knowledge and Preparedness of Dentists in Response to Bioterrorism(Wolters Kluwer, 2024-03-29) Chaitanya, Nallan CSK; Chelluri, Shreya Reddy; Saba, Asra; Priya, Sivan Padma; Hashim, Nada Tawfig; Shetty, Shishir Ram; Padmanabhan, Vivek; Shaga, Pranathi; Pulluri, Saraswathi Sravani; El Bahra, ShadiIn the current climate of heightened terrorist activity, the deliberate release or threat of biological agents like viruses, bacteria, fungi, or their toxins to induce sickness or death among civilians has become a genuine possibility. The most crucial action during a bioterrorist strike is early warning. The possibility of such an occurrence in dental setting is underestimated. Methods and Materials: Seventy five graduate students participated in the research. In a survey on zoonotic diseases, participants were asked whether they were familiar with the transmission from person to person, if the diseases caused significant morbidity and mortality, whether they were simple to produce and disseminate, and whether they posed a high risk of infection. Results: Graph Prism was used to examine the data. A single proportion test was used to determine the “Aware Not Aware” group. The first 10 questions assessed dentists objective knowledge of bioterrorism. The importance of the last six questions was determined by their analysis of dentists’ preparedness and desire to respond to a bioterrorism associated occurrence via perceived knowledge. Conclusion: Given the real danger they may face, dentists needed to be vigilant regarding the prevention, detection, and treatment of zoonotic illnesses transmitted in their offices or as a vector while being commended for their courage in the face of adversity.Item Effectiveness of Oral Health Education Interventions Using Braille on Oral Health among Visually Impaired Children: Proposal for a Systematic Review(Wolters Kluwer, 2024-02) Shankar, Kiran S.; Arumugham, Meighana; Mohammed, Minhaj Ahmed Amer; Kaur Sandhu, Sunpreet; Bennadi, Darshana; Verma, Jeetu; Pulluri, Saraswathi SravaniTo assess how oral health education (OHE) techniques using braille affect visually impaired children’s awareness of oral health, oral hygiene status and practices, plaque, gingival health, and dental caries status. From 2010 to 2020, a thorough literature search will be conducted for studies in the English language using PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, Google Scholar, and Open Grey. Data extraction will be done after two reviewers extensively evaluate the papers for qualifying requirements. In accordance with the research designs, a quality evaluation of the chosen studies will be conducted. With the use of the program Review Manager 5.3, a meta-analysis will be completed.Item Morphological Variation of Mandibular Molars in Rohilkhand Population: An Original Research(Wolters Kluwer, 2024-02) Singh, Tanu; Bathla, Saurav; Dutta, Saurav Kumar; Mohammed, Minhaj Ahmed Amer; Jethi, Navdeep; Chansoria, Harsh; Pulluri, Saraswathi SravaniIntroduction: In-depth knowledge of common and aberrant pulp morphology is essential for appropriate diagnosis and treatment planning before commencing root canal treatment. The radicular morphology of mandibular molars has been extensively studied. Considerable variation in the number of canals and roots found in these teeth has been reported. Aim: The purpose of this study is to investigate the root canal morphology of the mandibular molars among the Rohilkhand population using Dentascan. Materials and Methods: Dentascan images of mandibular molar were taken from 99 extracted teeth that were collected from the Department of Oral Surgery and Maxillofacial Surgery, Institute of Dental Sciences, Bareilly, and private clinics. The examination of root canal systems of the teeth was based on Vertucci’s classification. Results: The mandibular molar (n = 99) were taken. Out of the 99 teeth examined, three canals were seen in 60 (60.6%) teeth, four canals in 39 (39.4%) teeth, 3% had extra distal roots, and 6% with C-shaped canals. Conclusion: Among mandibular first molars, only 3% had three roots. Mesial roots of the first molar typically present with two canals and two apical foramina with type IV or II canal configuration. Most distal roots of the first molar presented with a type I canal configuration. The remainder were distributed mainly between types II, IV, III, and V. Among 99 mandibular molars, 6% had single C-shaped roots.Item Oral Health in Zero Gravity: A Comprehensive Review of Orofacial Effects and Countermeasures in Spaceflights(Cureus, 2023-11-19) Harika, Pedada Divya; Mehta, Karan Hiral; Pulluri, Saraswathi Sravani; Rana, Priyanka; Rajani, Hanmandla; Aiman, AyeshaSpace is a complex and challenging setting encompassing the region beyond Earth's atmosphere where astronauts and spacecraft operate. The unique conditions of spaceflights, particularly microgravity and radiation, pose significant challenges to astronaut health, including the orofacial region. It has effects on saliva production, microbial composition, and oral hygiene practices, which influence oral health status, such as increased risk of dental caries, gum diseases, oral discomfort, temporomandibular joint dysfunctions, sialoliths, pain and dysesthesia in the teeth and oral mucosa, masticatory muscle atrophy, and oral cancer which can be detrimental during prolonged missions. Hence, a comprehensive approach to dental care in space is imperative to ensure astronauts' well-being and overall health as we strive to extend our presence beyond Earth. This literature review paper sheds light on the intricate effects of space on the orofacial region and delves into the unique challenges astronauts face in upholding optimal oral health while in space. It explores the current state of dentistry in space and discusses advancements and strategies that aim to maintain optimal oral health for astronauts during extended space missions.