Examining the Effect of Introducing a Link from Electrical Excitation to Calcium Dynamics in a Cardiomyocyte
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Type of Work27 pages
Citation of Original PublicationAngeloff, Kallista; Barajas, Carlos A.; Middleton, Alexander; Osia, Uchenna; Graf, Jonathan S.; Gobbert, Matthias K.; and Coulibaly, Zana (2016) "Examining the Effect of Introducing a Link from Electrical Excitation to Calcium Dynamics in a Cardiomyocyte," Spora: A Journal of Biomathematics: Vol. 2: Iss.1, DOI: http://doi.org/10.30707/SPORA2.1Angeloff
RightsThis item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please contact the author.
SubjectsCalcium-induced calcium release
Contractile cardiac dynamics
Chemical cardiac dynamics
Electrical cardiac dynamics
High Performance Computing Facilty (HPCF)
Calcium dysregulation is a signi cant cause of fatal cardiac arrythmias, but it is an incompletely understood phenomenon and diffcult to predict. Cardiac calcium levels can be modeled as a system of partial differential equations linking the electrical excitation, calcium signaling, and mechanical contraction dynamics of the heart. A complete calcium-induced calcium release model uses reaction-diffusion equations to fully link these three systems. Simulations examine the effect of introducing the link from calcium signaling to electrical excitation. In particular, we perform a parameter study on the strength of the feedback connection with both links between calcium signaling and electrical excitation enabled. Simulations indicate that the feedback and feedforward between electrical excitation and calcium signaling can in uence the voltage in a physiologically realistic way.