Examining the Effect of Introducing a Link from Electrical Excitation to Calcium Dynamics in a Cardiomyocyte

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dc.contributor.authorAngeloff, Kallista
dc.contributor.authorBarajas, Carlos A.
dc.contributor.authorMiddleton, Alexander
dc.contributor.authorOsia, Uchenna
dc.contributor.authorGraf, Jonathan S.
dc.contributor.authorGobbert, Matthias K.
dc.contributor.authorCoulibaly, Zana
dc.date.accessioned2018-09-20T18:55:45Z
dc.date.available2018-09-20T18:55:45Z
dc.date.issued2016
dc.description.abstractCalcium dysregulation is a signi cant cause of fatal cardiac arrythmias, but it is an incompletely understood phenomenon and diffcult to predict. Cardiac calcium levels can be modeled as a system of partial differential equations linking the electrical excitation, calcium signaling, and mechanical contraction dynamics of the heart. A complete calcium-induced calcium release model uses reaction-diffusion equations to fully link these three systems. Simulations examine the effect of introducing the link from calcium signaling to electrical excitation. In particular, we perform a parameter study on the strength of the feedback connection with both links between calcium signaling and electrical excitation enabled. Simulations indicate that the feedback and feedforward between electrical excitation and calcium signaling can in uence the voltage in a physiologically realistic way.en_US
dc.description.sponsorshipThese results were obtained as part of the REU Site: Interdisciplinary Program in High Performance Computing (hpcreu.umbc.edu) in the Department of Mathematics and Statistics at the University of Maryland, Baltimore County (UMBC), in Summer 2016 [2]. This program is funded by the National Science Foundation (NSF), the National Security Agency (NSA), and the Department of Defense (DOD), with additional support from UMBC, the Department of Mathematics and Statistics, the Center for Interdisciplinary Research and Consulting (CIRC), and the UMBC High Performance Computing Facility (HPCF). HPCF is supported by the U.S. National Science Foundation through the MRI program (grant nos. CNS- 0821258 and CNS-1228778) and the SCREMS program (grant no. DMS-0821311), with additional substantial support from UMBC. Co-author Uchenna Osia was supported in part by the UMBC National Security Agency (NSA) Scholars Program through a contract with the NSA. Graduate assistant Jonathan Graf was supported by UMBC.en_US
dc.description.urihttps://ir.library.illinoisstate.edu/cgi/viewcontent.cgi?article=1011&context=sporaen_US
dc.format.extent27 pagesen_US
dc.genrejournal articleen_US
dc.identifierdoi:10.13016/M27D2QB59
dc.identifier.citationAngeloff, Kallista; Barajas, Carlos A.; Middleton, Alexander; Osia, Uchenna; Graf, Jonathan S.; Gobbert, Matthias K.; and Coulibaly, Zana (2016) "Examining the Effect of Introducing a Link from Electrical Excitation to Calcium Dynamics in a Cardiomyocyte," Spora: A Journal of Biomathematics: Vol. 2: Iss.1, DOI: http://doi.org/10.30707/SPORA2.1Angeloffen_US
dc.identifier.urihttp://doi.org/10.30707/SPORA2.1Angeloff
dc.identifier.urihttp://hdl.handle.net/11603/11336
dc.language.isoen_USen_US
dc.publisherIllinois State Universityen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Mathematics Department Collection
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please contact the author.
dc.subjectCalcium-induced calcium releaseen_US
dc.subjectCardiomyocytesen_US
dc.subjectContractile cardiac dynamicsen_US
dc.subjectChemical cardiac dynamicsen_US
dc.subjectElectrical cardiac dynamicsen_US
dc.subjectUMBC High Performance Computing Facility (HPCF)en_US
dc.titleExamining the Effect of Introducing a Link from Electrical Excitation to Calcium Dynamics in a Cardiomyocyteen_US
dc.typeTexten_US

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