Neuropathology of Suicide A Review and an Approach
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Date
2006-12-17
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Citation of Original Publication
Bachus, Susan E.; Hyde, Thomas M.; Akil, Mayada; Weickert, Cynthia Shannon; Vawter, Marquis P.; Kleinman, Joel E.; Neuropathology of Suicide A Review and an Approach; Annals of the new york academic of sciences 836,1 (2006); https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1997.tb52361.x?sid=nlm%3Apubmed
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This work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
Public Domain Mark 1.0
This work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
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Abstract
Neuropathology is one approach to the effort to elucidate the pathophysiology of suicide. Initial neurochemical studies focusing on the roles of serotonin (5‐HT) and noradrenaline (NE) abnormalities in brains of suicide victims have been somewhat inconsistent. More recently developed methodologies, including quantitative receptor autoradiography, immunoblotting, immunohistochemistry, cell morphometry, in situ hybridization, Northern analysis, solution hybridization/RNase protection assay, reverse transcriptase polymerase chain reaction, and genotyping, which have already been applied successfully in studies of other disorders of brain structure or function, are now increasingly being adopted for postmortem studies of suicide. These new strategies are adding convergent evidence for brain 5‐HT and NE dysfunction in the etiology of suicide susceptibility, refining the neuroanatomical localization of this dysfunction, and in addition, implicating heretofore unsuspected candidate neurotransmitter systems in the neuropathological substrates of suicide susceptibility. It is argued here that the confluence of the availability of suitable postmortem samples and this augmentation of our armamentarium of techniques promises the attainment of important new insights into the biological underpinings of suicide from postmortem research. It is to be hoped that this new knowledge might inspire novel inspire novel pharmacotherapeutic strategies for the prevention of suicide.