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    Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells

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    https://www.pnas.org/content/99/5/3024.long
    Permanent Link
    https://doi.org/10.1073/pnas.052678899
    http://hdl.handle.net/11603/21193
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    • UMBC Chemical, Biochemical & Environmental Engineering Department
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    Author/Creator
    Teng, Yang D.
    Lavik, Erin
    Qu, Xianlu
    Park, Kook I.
    Ourednik, Jitka
    Zurakowski, David
    Langer, Robert
    Snyder, Evan Y.
    Date
    2002-03-05
    Type of Work
    7 pages
    Text
    conference papers and proceedings
    Citation of Original Publication
    Yang D. Teng, Erin B. Lavik, Xianlu Qu, Kook I. Park, Jitka Ourednik, David Zurakowski, Robert Langer, Evan Y. Snyder, Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells, Proceedings of the National Academy of Sciences Mar 2002, 99 (5) 3024-3029; DOI: 10.1073/pnas.052678899
    Rights
    This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
    Subjects
    spinal cord injury
    neural stem cells
    multicomponent polymer scaffold
    functional long-term improvement
    Abstract
    To better direct repair following spinal cord injury (SCI), we designed an implant modeled after the intact spinal cord consisting of a multicomponent polymer scaffold seeded with neural stem cells. Implantation of the scaffold–neural stem cells unit into an adult rat hemisection model of SCI promoted long-term improvement in function (persistent for 1 year in some animals) relative to a lesion-control group. At 70 days postinjury, animals implanted with scaffold-plus-cells exhibited coordinated, weight-bearing hindlimb stepping. Histology and immunocytochemical analysis suggested that this recovery might be attributable partly to a reduction in tissue loss from secondary injury processes as well as in diminished glial scarring. Tract tracing demonstrated corticospinal tract fibers passing through the injury epicenter to the caudal cord, a phenomenon not present in untreated groups. Together with evidence of enhanced local GAP-43 expression not seen in controls, these findings suggest a possible regeneration component. These results may suggest a new approach to SCI and, more broadly, may serve as a prototype for multidisciplinary strategies against complex neurological problems


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    Albin O. Kuhn Library & Gallery
    University of Maryland, Baltimore County
    1000 Hilltop Circle
    Baltimore, MD 21250
    www.umbc.edu/scholarworks

    Contact information:
    Email: scholarworks-group@umbc.edu
    Phone: 410-455-3544


    If you wish to submit a copyright complaint or withdrawal request, please email mdsoar-help@umd.edu.