CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo

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https://www.sciencedirect.com/science/article/abs/pii/S0014488606006376

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https://doi.org/10.1016/j.expneurol.2006.12.013
 http://hdl.handle.net/11603/21201

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UMBC Chemical, Biochemical & Environmental Engineering Department

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2006-12-20

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journal articles postprints
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Jason F. Talbott, Qilin Cao et al., CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo, Exp Neurol. 2007 March ; 204(1): 485–489, DOI: https://doi.org/10.1016/j.expneurol.2006.12.013

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Abstract

Delivery of factors capable of promoting oligodendrocyte precursor cell (OPC) survival and differentiation in vivo is an important therapeutic strategy for a variety of pathologies in which demyelination is a component, including multiple sclerosis and spinal cord injury. Ciliary neurotrophic factor (CNTF) is a neuropoietic cytokine that promotes both survival and maturation of a variety of neuronal and glial cell populations, including oligodendrocytes. Present results suggest that, although CNTF has a potent survival and differentiation promoting effect in vitro on OPCs isolated from the adult spinal cord, CNTF administration in vivo is not sufficient to promote oligodendrocyte remyelination in the glial-depleted environment of unilateral ethidium bromide (EB) lesions.