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    Advances in zinc sensors for studying zinc release events from pancreatic cells

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    638002.pdf (826.6Kb)
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    https://www.spiedigitallibrary.org/conference-proceedings-of-spie/6380/638002/Advances-in-zinc-sensors-for-studying-zinc-release-events-from/10.1117/12.690653.short?SSO=1
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    https://doi.org/10.1117/12.690653
    http://hdl.handle.net/11603/21351
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    Author/Creator
    Rosenzweig, Zeev
    Rosenzweig, Nitsa
    Crivat, Georgeta
    Date
    2006-10-25
    Type of Work
    9 pages
    Text
    conference papers and proceedings
    Citation of Original Publication
    Rosenzweig, Zeev; Rosenzweig, Nitsa; Crivat, Georgeta; Advances in zinc sensors for studying zinc release events from pancreatic cells; Proceedings Volume 6380, Smart Medical and Biomedical Sensor Technology IV; 638002 (2006); https://www.spiedigitallibrary.org/conference-proceedings-of-spie/6380/638002/Advances-in-zinc-sensors-for-studying-zinc-release-events-from/10.1117/12.690653.short?SSO=1
    Rights
    This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
    ©2006 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited
    Abstract
    This paper describes the fabrication and characterization of the analytical properties of fluorescence-based zinc ion sensing glass slides and antibody based zinc sensors and their application in monitoring zinc release from beta pancreatic cells. The zinc ion indicator ZnAF-2 {6-[N- [N', N'-bis (2-pyridinylmethyl)-2-aminoethyl] amino-3',6'-dihydroxy-spiro[isobenzofuran-1(3H),9'-[9H] xanthene]-3-one} was modified to include a sufficiently long linking aliphatic chain, with a terminal carboxyl functional group. The activated carboxyl-modified ZnAF-2 was conjugated to the amino silanized surface of glass slides and to free amino groups of the A2B5 antibody molecules. The sensors were used to monitor zinc ion release events from glucose-stimulated pancreatic cells.


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    Albin O. Kuhn Library & Gallery
    University of Maryland, Baltimore County
    1000 Hilltop Circle
    Baltimore, MD 21250
    www.umbc.edu/scholarworks

    Contact information:
    Email: scholarworks-group@umbc.edu
    Phone: 410-455-3021


    If you wish to submit a copyright complaint or withdrawal request, please email mdsoar-help@umd.edu.