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dc.contributor.authorPolf, Jerimy
dc.contributor.authorBarajas, Carlos A.
dc.contributor.authorKroiz, Gerson C.
dc.contributor.authorPeterson, Stephen W.
dc.contributor.authorMaggi, Paul
dc.contributor.authorMackin, Dennis S.
dc.contributor.authorBeddar, Sam
dc.contributor.authorGobbert, Matthias
dcterms.creatorhttps://orcid.org/0000-0003-1745-2293en_US
dc.date.accessioned2022-05-02T14:13:36Z
dc.date.available2022-05-02T14:13:36Z
dc.date.issued2021-06-25
dc.description.abstractWe present Compton camera (CC) based PG imaging for proton range verification at clinical dose rates. PG emission from a tissue-equivalent phantom during irradiation with clinical proton beams was measured with a prototype CC. Images were reconstructed of the raw measured data and of data processed with a neural network (NN) trained to identify “true” and “false” PG events. From these images, we determine if PG images produced by the prototype CC could provide clinically useful information about the in vivo range of the proton beams delivered during proton beam radiotherapy. NN processing of the data was found necessary to allow identification of the proton beam path from the PG images. Furthermore, to allow the localization of the end of the proton beam range with a precision of ≤ 3mm with the prototype CC, ~1 x 10⁹ protons would need to be delivered, which is on the order of magnitude delivered for a standard proton radiotherapy treatment field. To obtain higher precision in beam range determination and to allow imaging a single proton pencil beam delivered within the full treatment field, further improvements in PG detection rates by the CC, NN data processing, and image reconstruction algorithms are needed.en_US
dc.description.sponsorshipThe research reported in this publication was supported by the National Institutes of Health National Cancer Institute under award number R01CA187416. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Data used for this work was generated using resources of the UMBC High Performance Computing Facility(HPCF; https://hpcf.umbc.edu), which is supported by the U.S. National Science Foundation through the MRI program (grant nos. CNS–0821258, CNS–1228778, and OAC–1726023) and the SCREMS program (grant no. DMS–0821311).en_US
dc.format.extent13 pagesen_US
dc.genreconference papers and proceedingsen_US
dc.genrepreprintsen_US
dc.identifierdoi:10.13016/m2dyxc-vju6
dc.identifier.citationJerimy C. Polf, Carlos A. Barajas, Gerson C. Kroiz, Stephen W. Peterson, Paul Maggi, Dennis S. Mackin, Sam Beddar, and Matthias K. Gobbert. A Study of the Clinical Viability of a Prototype Compton Camera for Prompt Gamma Imaging Based Proton Beam Range Verification.en_US
dc.identifier.urihttp://hdl.handle.net/11603/24661
dc.language.isoen_USen_US
dc.publisherAAPMen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Mathematics Department Collection
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectUMBC High Performance Computing Facility (HPCF)en_US
dc.titleA Study of The Clinical Viability of A Prototype Compton Camera for Prompt Gamma Imaging Based Proton Beam Range Verificationen_US
dc.typeTexten_US


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This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
Except where otherwise noted, this item's license is described as This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.