Determining Biological Significance Of Putative Exons Through The Application Of Annotation-Agnostic Methods To Measure Potential Hallmarks Of Functionality
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Author/Creator ORCID
Date
2022-05
Department
Hood College Biology
Program
Biomedical and Environmental
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Abstract
The aim of this study is to infer the potential for biological function of putative exons
which arise from repetitive element (REL) exonization events in human brain tissues.
The data pipeline in this project utilizes existing annotation-agnostic methods and public
RNA-seq data consortiums to determine the exact boundaries and levels of expression of
these putative exons which may be unrepresented in current gene annotations. Biological
function of putative exons is assessed by examining splicing events which could give rise
to novel transcripts that contain these putative exons. These splicing events are assessed
in regard to overall expression, prevalence across samples, and tissue specificity.
Documentation and source code is available at:
https://github.com/biancabifx/PutativeExonFunctionPipeline.