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    Using yeast to define the regulatory role of protein methylation

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    nihms-1065310.pdf (534.3Kb)
    Links to Files
    https://www.eurekaselect.com/article/101832
    Permanent Link
    https://doi.org/10.2174%2F1389203720666191023150727
    http://hdl.handle.net/11603/26709
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    • UMBC Biological Sciences Department
    • UMBC Faculty Collection
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    Author/Creator
    Jethmalani, Yogita
    Green, Erin
    Author/Creator ORCID
    https://orcid.org/0000-0003-3422-8356
    https://orcid.org/0000-0003-3923-6726
    Date
    2021-01-01
    Type of Work
    15 pages
    Text
    journal articles
    postprints
    Citation of Original Publication
    Jethmalani Yogita and Green M. Erin *, Using Yeast to Define the Regulatory Role of Protein Lysine Methylation, Current Protein & Peptide Science 2020; 21(7) . https://dx.doi.org/10.2174/1389203720666191023150727
    Rights
    The published manuscript is available at EurekaSelect via https://www.eurekaselect.com/openurl/content.php?genre=article&doi=http://dx.doi.org/10.2174/1389203720666191023150727.
    Abstract
    The post-translational modification (PTM) of proteins are crucial for cells to survive under diverse environmental conditions and to respond to stimuli. PTMs are known to govern a broad array of cellular processes including signal transduction and chromatin regulation. The PTM lysine methylation has been extensively studied within the context of chromatin and the epigenetic regulation of the genome. However, it has also emerged as a critical regulator of non-histone proteins important for signal transduction pathways. While the number of known non-histone protein methylation events is increasing, the molecular functions of many of these modifications are not yet known. Proteomic studies of the model system Saccharomyces cerevisiae suggest lysine methylation may regulate a diversity of pathways including transcription, RNA processing, translation, and signal transduction cascades. However, there has still been relatively little investigation of lysine methylation as a broad cellular regulator beyond chromatin and transcription. Here, we outline our current state of understanding of non-histone protein methylation in yeast and propose ways in which the yeast system can be leveraged to develop a much more complete picture of molecular mechanisms through which lysine methylation regulates cellular functions.


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    Albin O. Kuhn Library & Gallery
    University of Maryland, Baltimore County
    1000 Hilltop Circle
    Baltimore, MD 21250
    www.umbc.edu/scholarworks

    Contact information:
    Email: scholarworks-group@umbc.edu
    Phone: 410-455-3021


    If you wish to submit a copyright complaint or withdrawal request, please email mdsoar-help@umd.edu.