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    Fate of transition metals in PO₄-based in vitro assays: equilibrium modeling and macroscopic studies

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    D0EM00405G.pdf (1.134Mb)
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    https://pubs.rsc.org/en/content/articlelanding/2021/em/d0em00405g
    Permanent Link
    https://doi.org/10.1039/D0EM00405G
    http://hdl.handle.net/11603/29707
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    • UMBC Chemical, Biochemical & Environmental Engineering Department
    • UMBC Faculty Collection
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    Author/Creator
    Reed, Brian
    Yalamanchili, Jayashree
    Leach, Jennie
    Hennigan, Christopher
    Author/Creator ORCID
    https://orcid.org/0000-0001-7155-3671
    https://orcid.org/0000-0003-1905-575X
    https://orcid.org/0000-0002-6212-4362
    https://orcid.org/0000-0002-2454-2838
    Date
    2021-01-01
    Type of Work
    34 pages
    Text
    journal articles
    preprints
    Citation of Original Publication
    Reed, Brian E., Jayashree Yalamanchili, Jennie B. Leach, and Christopher J. Hennigan. “Fate of Transition Metals in PO₄-Based in Vitro Assays: Equilibrium Modeling and Macroscopic Studies.” Environmental Science: Processes & Impacts 23, no. 1 (February 4, 2021): 160–69. https://doi.org/10.1039/D0EM00405G.
    Rights
    This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
    Abstract
    Transition metals are thought to be among the most toxic components in atmospheric particulate matter (PM) due to their role in catalyzing reactive oxygen species (ROS) formation. We show that precipitation of the transition metals Fe(II), Fe(III), and Mn(II) are thermodynamically favored in phosphate-based assays used to measure the oxidative potential (OP) – a surrogate for toxicity – of PM. Fe and Mn precipitation is likely to occur at extremely low metal concentrations (<0.5 μM), levels that are imperceptible to the naked eye. The concentration of each metal (other than Cu) in aqueous PM filter extracts often exceeds the solubility limit in OP assays, indicating favorable thermodynamic conditions for precipitation. Macroscopic experimental results at higher metal concentrations (>100 μM) with visible precipitates provide quasi-validation of the thermodynamic modeling. Oxidation of Fe(II) to Fe(III) is likely to be rapid in all in vitro OP assays, transforming Fe to a much less soluble form. Fe precipitates are likely to increase the rate of precipitation of other metals and possibly induce co-precipitation. These results have direct relevance for all PO₄-based assays; the implications for studies of PM toxicity are discussed.


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    Albin O. Kuhn Library & Gallery
    University of Maryland, Baltimore County
    1000 Hilltop Circle
    Baltimore, MD 21250
    www.umbc.edu/scholarworks

    Contact information:
    Email: scholarworks-group@umbc.edu
    Phone: 410-455-3544


    If you wish to submit a copyright complaint or withdrawal request, please email mdsoar-help@umd.edu.