• Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node 

  Simon, Thomas; Li, Lushen; Wagner, Chelsea; Zhang, Tianshu; Saxena, Vikas; Brinkman, C. Colin; Tostanoski, Lisa H; Ostrand-Rosenberg, Suzanne; Jewell, Chris; Shea-Donohue, Terez; Hippen, Keli; Blazar, Bruce; Abdi, Reza; Bromberg, Jonathan S (Wolters Kluwer Health, 2019-10-01)

  Background. Stromal laminins α4 and α5 are differentially regulated in transplant tolerance and immunity, respectively, resulting in altered T-cell trafficking. We hypothesized that laminins directly regulated T-cell ...

• Lisinopril preserves physical resilience and extends life span in a genotype-specific manner in Drosophila melanogaster 

  Gabrawy, Mariann M.; Campbell, Sarah; Carbone, Mary Anna; Morozova, Tatiana V.; Arya, Gunjan H.; Turlapati, Lavanya B.; Walston, Jeremy D.; Starz-Gaiano, Michelle; Everett, Logan; Mackay, Trudy F. C.; Leips, Jeff; Abadir, Peter M. (Oxford University Press, 2019-06-14)

  Physical resiliency declines with age and comorbid conditions. In humans, Angiotensin Converting Enzyme (ACE) has been associated with attenuation of the decline in physical performance with age. ACE-inhibitor (ACEi) ...

• Functionally Significant Features in the 5' Untranslated Region of the ABCA1 Gene and Their Comparison in Vertebrates 

  Dvorak, Pavel; Leupen, Sarah; Soucek, Pavel (MDPI, 2019-06-21)

  Single nucleotide polymorphisms located in 5' untranslated regions (50UTRs) can regulate gene expression and have clinical impact. Recognition of functionally significant sequences within 5' UTRs is crucial in next-generation ...

• LUX ARRHYTHMO mediates crosstalk between the circadian clock and defense in Arabidopsis 

  Zhang, Chong; Gao, Min; Seitz, Nicholas C.; Angel, William; Hallworth, Amelia; Wiratan, Linda; Darwish, Omar; Alkharouf, Nadim; Dawit, Teklu; Lin, Daniela; Egoshi, Riki; Wang, Xiping; McClung, C. Robertson; Lu, Hua (Springer Nature Limited, 2019-06-11)

  The circadian clock is known to regulate plant innate immunity but the underlying mechanism of this regulation remains largely unclear. We show here that mutations in the core clock component LUX ARRHYTHMO (LUX) disrupt ...

• Rgma-Induced Neo1 Proteolysis Promotes Neural Tube Morphogenesis 

  Brown, Sharlene; Jayachandran, Pradeepa; Negesse, Maraki; Olmo, Valerie; Vital, Eudorah; Brewster, Rachel (Society for NeuroScience, 2019-09-18)

  Neuroepithelial cell (NEC) elongation is one of several key cell behaviors that mediate the tissue-level morphogenetic movements that shape the neural tube (NT), the precursor of the brain and spinal cord. However, the ...

• Mapping of ribosomal protein genes by in vitro protein synthesis using DNA fragments of lambda fus3 transducing phage DNA as templates 

  Lindahl, Lasse; Post, Leonard; Zengel, Janice; Gilbert, Scott F.; Strycharz, William A.; Nomura, Masayasu (1977-10-25)

  hfus3 (or hfus2) transducing phage stimulates the synthesis of 27 ribosomal proteins, elongation factors EF-Tu and EF-G, and RNA polymerase subunit (Y in ultraviolet-irradiated Escherichia roli cells (see a preceding ...

• Cluster of genes in Escherichia coli for ribosomal proteins, ribosomal RNA, and RNA polymerase subunits 

  Lindahl, L.; Jaskunas, S. R.; Dennis, P. P.; Nomura, M. (National Academy of Sciences, 1975-07-01)

  This work was supported in part by the College of Agriculture and Life Sciences, University of Wisconsin, and by grants from the National Science Foundation (GB31086) and the National Institute of General Medical Sciences ...

• Specialized transducing phages for ribosomal protein genes of Escherichia coli 

  Jaskunas, S. R.; Lindahl, L.; Nomura, M. (National Academy of Sciences, 1975-01-01)

  Specialized lambda transducing phages have been isolated carrying approximately half the ribosomal protein genes of E. coli. These phages carry regions of the bacterial chromosome between aroE and fus. The ribosomal protein ...

• The small and large ribosomal subunits depend on each other for stability and accumulation 

  Gregory, Brian; Rahman, Nusrat; Bommakanti, Ananth; Shamsuzzaman, Md; Thapa, Mamata; Lescure, Alana; Zengel, Janice M.; Lindahl, Lasse (Life Science Alliance, 2019-03-05)

  The 1:1 balance between the numbers of large and small ribosomal subunits can be disturbed by mutations that inhibit the assembly of only one of the subunits. Here, we have investigated if the cell can counteract an imbalance ...

• Analysis of cell cycle parameters during the transition from unhindered growth to ribosomal and translational stress conditions 

  Shamsuzzaman, Md; Bommakanti, Ananth; Zapinsky, Aviva; Rahman, Nusrat; Pascual, Clarence; Lindahl, Lasse (PLOS, 2017-10-13)

  Abrogation of ribosome synthesis (ribosomal stress) leads to cell cycle arrest. However, the immediate cell response to cessation of ribosome formation and the transition from normal cell proliferation to cell cycle arrest ...

• The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel 

  Wekselman, Itai; Zimmerman, Ella; Davidovich, Chen; Lindahl, Lasse; Zengel, Janice M.; Yonath, Ada (Cell Press, 2017-08-01)

  Erythromycin is a clinically useful antibiotic that binds to an rRNA pocket in the ribosomal exit tunnel. Commonly, resistance to erythromycin is acquired by alterations of rRNA nucleotides that interact with the drug. ...

• The extended loops of ribosomal proteins uL4 and uL22 of Escherichia coli contribute to ribosome assembly and protein translation 

  Lawrence, Marlon G.; Shamsuzzaman, M.d.; Kondopaka, Maithri; Pascual, Clarence; Zengel, Janice M.; Lindahl, Lasse (Oxford University Press, 2016-06-01)

  Nearly half of ribosomal proteins are composed of a domain on the ribosome surface and a loop or extension that penetrates into the organelle's RNA core. Our previous work showed that ribosomes lacking the loops of ribosomal ...

• A new system for naming ribosomal proteins 

  Ban, Nenad; Beckmann, Roland; Cate, Jamie H.D.; Dinman, Jonathan D.; Dragon, François; Ellis, Steven R.; Lafontaine, Denis L.J.; Lindahl, Lasse; Liljas, Anders; Lipton, Jeffrey M.; McAlear, Michael A.; Moore, Peter B.; Noller, Harry F.; Ortega, Joaquin; Panse, Vikram Govind; Ramakrishnan, V.; Spahn, Christian M.T.; Steitz, Thomas A.; Tchorzewski, Marek; Tollervey, David; Warren, Alan J.; Williamson, James R.; Wilson, Daniel; Yonath, Ada; Yusupov, Marat (Elsevier Ltd, 2014-02-10)

  A system for naming ribosomal proteins is described that the authors intend to use in the future. They urge others to adopt it. The objective is to eliminate the confusion caused by the assignment of identical names to ...

• Repressed synthesis of ribosomal proteins generates protein-specific cell cycle and morphological phenotypes 

  Thapa, Mamata; Bommakanti, Ananth; Shamsuzzaman, Md.; Gregory, Brian; Samsel, Leigh; Zengel, Janice M.; Lindahl, Lasse (American Society for Cell Biology, 2013-10-09)

  The biogenesis of ribosomes is coordinated with cell growth and proliferation. Distortion of the coordinated synthesis of ribosomal components affects not only ribosome formation, but also cell fate. However, the connection ...

• RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway 

  Lindahl, Lasse; Bommankanti, Ananth; Li, Xing; Hayden, Lauren; Jones, Adrienne; Khan, Miriam; Oni, Tolulope; Zengel, Janice M. (The RNA Society, 2009-07)

  RNase MRP is a nucleolar RNA–protein enzyme that participates in the processing of rRNA during ribosome biogenesis. Previous experiments suggested that RNase MRP makes a nonessential cleavage in the first internal transcribed ...

• Comparative studies on translation arrest in the CrbCmlA and SecM Peptides 

  Lawrence, Marlon G.; Lindahl, Lasse; Zengel, Janice M. (American Society for Microbiology, 2008-06-27)

  Amino acids are polymerized into peptides in the peptidyl transferase center of the ribosome. The nascent peptides then pass through the exit tunnel before they reach the extraribosomal environment. A number of nascent ...

• Mutation from guanine to adenine in 25S rRNA at the position equivalent to E. coli A2058 does not confer erythromycin sensitivity in Sacchromyces cerevisae 

  Bommakanti, Ananth S.; Lindahl, Lasse; Zengel, Janice M. (The RNA Society, 2008-03)

  The macrolide erythromycin binds to the large subunit of the prokaryotic ribosome near the peptidyltransferase center (PTC) and inhibits elongation of new peptide chains beyond a few amino acids. Nucleotides A2058 and ...

• Regulation of Ribosomal Protein Synthesis in Vibrio cholerae 

  Allen, Todd D.; Watkins, Tonya; Lindahl, Lasse; Zengel, Janice M. (American Society for Microbiology, 2004-09)

  We have investigated the regulation of the S10 and spc ribosomal protein (r-protein) operons in Vibrio cholerae. Both operons are under autogenous control; they are mediated by r-proteins L4 and S8, respectively. Our results ...

• Identification of a functional core in the RNA component of RNase MRP of budding yeasts 

  Li, Xing; Zaman, Sephorah; Langdon, Yvette; Zengel, Janice M.; Lindahl, Lasse (Oxford University Press, 2004-07-14)

  RNase MRP is an endonuclease participating in ribosomal RNA processing. It consists of one RNA and at least nine protein subunits. Using oligonucleotide-directed mutagenesis, we analyzed the functional role of five of the ...

• The extended loops of ribosomal proteins L4 and L22 are not required for ribosome assembly or L4-mediated autogenous control 

  Zengel, Janice M.; Jerauld,  Adam; Walker,  Andre; Wahl,  Markus C.; Lindahl,  Lasse (The RNA Society, 2003-10)

  Ribosomal proteins L4 and L22 both have a globular domain that sits on the surface of the large ribosomal subunit and an extended loop that penetrates its core. The tips of both loops contribute to the lining of the peptide ...

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