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    Melatonin for Sedative Withdrawal in Older Patients with Primary Insomnia: a Randomized Double-Blind Placebo-Controlled Trial

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    http://hdl.handle.net/11603/7910
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    Author/Creator
    Lähteenmäki, Ritva
    Puustinen, Juha
    Vahlberg, Tero
    Lyles, Alan
    Neuvonen, Pertti J
    Partinen, Markku
    Räihä, Ismo
    Kivelä, Sirkka-Liisa
    Date
    2014-06
    Type of Work
    17
    Text
    journal articles
    Citation of Original Publication
    Lähteenmäki, R., Puustinen, J., Vahlberg T., Lyles, A., Neuvonen, P.J., Partinen P., Räihä, I., Kivelä, S. (2014) Melatonin for Sedative Withdrawal in Older Patients with Primary Insomnia: a Randomised Double-Blind Placebo-Controlled Trial. British Journal of Clinical Pharmacology. doi: 10.1111/bcp.12294.
    Subjects
    controlled trial
    melatonin
    temazepam
    withdrawal
    zolpidem
    zopiclone
    Abstract
    We compared the efficacy of melatonin and placebo as adjuvants in the withdrawal of patients from long term temazepam, zopiclone or zolpidem (here ‘BZD’) use. Gradual dose reduction of BZDs combined with CRM or placebo, and psychosocial support produced high short term and moderate long term BZD abstinence. CRM showed no withdrawal benefit compared with placebo.


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    Robert L. Bogomolny Library
    University of Baltimore
    1420 Maryland Ave.
    Baltimore, MD 21201
    Email: knowledgeworks@ubalt.edu


    If you wish to submit a copyright complaint or withdrawal request, please email mdsoar-help@umd.edu.