Finding the sweet spot: a library of hydrogels with tunable degradation for tissue model development

Simple item page
dc.contributor.authorPandala, Narendra
dc.contributor.authorLaScola, Michael A.
dc.contributor.authorHinton, Zachary
dc.contributor.authorKorley, LaShanda T.J.
dc.contributor.authorLavik, Erin
dc.date.accessioned2022-04-12T14:00:23Z
dc.date.available2022-04-12T14:00:23Z
dc.date.issued2022-03-07
dc.description.abstractIn vitro models are valuable tools for applications including understanding cellular mechanisms and drug screening. Hydrogel biomaterials facilitate in vitro models by mimicking the extracellular matrix and in vivo microenvironment. However, it can be challenging for cells to form tissues in hydrogels that do not degrade. In contrast, if hydrogels degrade too much or too quickly, tissue models may be difficult to assess in a high throughput manner. In this paper, we present a poly(allylamine) (PAA) based synthetic hydrogel system which can be tuned to control the mechanical and chemical cues provided by the hydrogel scaffold. PAA is a polycation with several biomedical applications, including the delivery of small molecules, nucleic acids, and proteins. Based on PAA and poly(ethylene glycol) (PEG), we developed a synthetic non-degradable system with potential applications for long-term cultures. We then created a second set of gels that combined PAA with poly-L-lysine (PLL) to generate a library of semi-degradable gels with unique degradation kinetics. In this work, we present the hydrogel systems’ synthesis, characterization, and degradation profiles along with cellular data demonstrating that a subset of gels supports the formation of endothelial cell cord-like structures.en_US
dc.description.urihttps://pubs.rsc.org/en/content/articlelanding/2022/tb/d1tb02436a/unauthen_US
dc.format.extent21 pagesen_US
dc.genrejournal articlesen_US
dc.genrepreprintsen_US
dc.identifierdoi:10.13016/m2qu1p-gekr
dc.identifier.citationPandala, Narendra et al. Finding the sweet spot: a library of hydrogels with tunable degradation for tissue model development. Journal of Materials Chemistry B (Mar 2022). https://doi.org/10.1039/D1TB02436Aen_US
dc.identifier.urihttps://doi.org/10.1039/D1TB02436A
dc.identifier.urihttp://hdl.handle.net/11603/24531
dc.language.isoen_USen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.relation.ispartofUMBC Staff Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC College of Engineering and Information Technology Dean's Office
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en_US
dc.titleFinding the sweet spot: a library of hydrogels with tunable degradation for tissue model developmenten_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0002-3057-8327en_US
dcterms.creatorhttps://orcid.org/0000-0002-0644-744Xen_US

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
PEG-PAA-paper-v6.pdf
Size:
1.39 MB
Format:
Adobe Portable Document Format
Description:
Download
Thumbnail Image
Name:
d1tb02436a1.pdf
Size:
2.9 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.56 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

UMBC Chemical, Biochemical & Environmental Engineering Department
UMBC College of Engineering and Information Technology Dean's Office
UMBC Faculty Collection
UMBC Staff Collection