Tricyclic 2′-C-Modified Nucleosides as Potential Anti-HCV Therapeutics

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dc.contributor.authorWauchope, Orrette
dc.contributor.authorTomney, Matthew James
dc.contributor.authorPepper, Joseph L.
dc.contributor.authorKorba, Brent E.
dc.contributor.authorSeley-Radtke, Katherine
dc.date.accessioned2025-07-30T19:22:48Z
dc.date.issued2010-09-16
dc.description.abstractPromising biological activity in a number of therapeutic areas has been reported for both tricyclic nucleosides and 2′-modified nucleosides. In particular, disubstitution at the C-2′ position of nucleosides has resulted in significant activity against the hepatitis C virus (HCV). Combining this with the observation that tricyclic nucleosides developed in our laboratory have been shown to inhibit the RNA-dependent RNA polymerase NS5B led to the design of a series of 2′-modified tricyclic nucleosides. Details of the synthesis, structural characterization, and preliminary biological results are reported.
dc.description.sponsorshipThis work was generously supported by the National Institutes of Health (R01 GM076345, KSR). The anti-HCV assays were supported by NIAID contract N01-AI-30046 to GUMC (BEK). We are thankful for this support.
dc.description.urihttps://pubs.acs.org/doi/10.1021/ol101482h
dc.format.extent9 pages
dc.genrejournal articles
dc.genrepostprints
dc.identifierdoi:10.13016/m2li39-3ta8
dc.identifier.citationWauchope, Orrette R., Matthew J. Tomney, Joseph L. Pepper, Brent E. Korba, and Katherine L. Seley-Radtke. “Tricyclic 2′-C-Modified Nucleosides as Potential Anti-HCV Therapeutics.” Organic Letters 12, no. 20 (October 15, 2010): 4466–69. https://doi.org/10.1021/ol101482h.
dc.identifier.urihttps://doi.org/10.1021/ol101482h
dc.identifier.urihttp://hdl.handle.net/11603/39601
dc.language.isoen_US
dc.publisherACS
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.relation.ispartofUMBC Student Collection
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/ol101482h.
dc.subjectUMBC Meyerhoff Graduate Fellows Program
dc.titleTricyclic 2′-C-Modified Nucleosides as Potential Anti-HCV Therapeutics
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-0154-3459

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