Chemical Modification of Pseudomonas aeruginosa Exotoxin A

Abstract

The author would like to thank Dr. Stephen H. Leppla for his suggestions during the course of the work described in this thesis, and for the independence assigned the author throughout the past three years under his employment. The author thanks Ms. Rebecca B. Dorland for her assistance with the binding assay, for her typing of this thesis, and for her encouragement during the course of the work described in this thesis. Dr. John L. Middlebrook is recognized for his guidance with the portion of this work concerning circular dichroism, Mr. Richard Dinterman for assistance with the amino acid analyzer, and Ms. Karen Bostian for the protein analyses. Dr. Harold Neufeld, Dr. Stephen H. Leppla, Dr. John L. Middlebrook, and Dr. Sidney J. Silverman are thanked .for their advice on the preparation of this thesis. Ms. Phebe Summers is thanked for the preparation of the figures in this thesis.