Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2
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Tao Peng et al., Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2, Appl. Phys. Lett. 117, 120601 (2020); https://doi.org/10.1063/5.0021842
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This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Tao Peng et al., Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2, Appl. Phys. Lett. 117, 120601 (2020); https://doi.org/10.1063/5.0021842 and may be found at https://aip.scitation.org/doi/10.1063/5.0021842.
Access to this item will begin on 09/24/2021
This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Tao Peng et al., Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2, Appl. Phys. Lett. 117, 120601 (2020); https://doi.org/10.1063/5.0021842 and may be found at https://aip.scitation.org/doi/10.1063/5.0021842.
Access to this item will begin on 09/24/2021
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Abstract
Lateral flow assay (LFA) has long been used as a biomarker detection technique. It has advantages such as low cost, rapid readout, portability, and ease of use. However, its qualitative readout process and lack of sensitivity are limiting factors. We report a photon-counting approach to accurately quantify LFAs while enhancing sensitivity. In particular, we demonstrate that the density of SARS-CoV-2 antibodies can be quantified and measured with an enhanced sensitivity using this simple laser optical analysis.