Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2

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dc.contributor.authorPeng, Tao
dc.contributor.authorLiu, Xiangpei
dc.contributor.authorAdams, L. Garry
dc.contributor.authorAgarwal, Girish
dc.contributor.authorAkey, Bruce
dc.contributor.authorCirillo, Jeffrey
dc.contributor.authorDeckert, Volker
dc.contributor.authorDelfan, Sahar
dc.contributor.authorFry, Edward
dc.contributor.authorHan, Zehua
dc.contributor.authorHemmer, Philip
dc.contributor.authorKattawar, George
dc.contributor.authorKim, Moochan
dc.contributor.authorLee, Ming-Che
dc.contributor.authorLu, Chaoyang
dc.contributor.authorMogford, Jon
dc.contributor.authorNessler, Reed
dc.contributor.authorNeuman, Ben
dc.contributor.authorNie, Xiaoyu
dc.contributor.authorPan, Jianwei
dc.contributor.authorPryor, Jane
dc.contributor.authorRajil, Navid
dc.contributor.authorShih, Yanhua
dc.contributor.authorSokolov, Alexei
dc.contributor.authorSvidzinsky, Anatoly
dc.contributor.authorWang, Dawei
dc.contributor.authorYi, Zhenhuan
dc.contributor.authorZheltikov, Aleksei
dc.contributor.authorScully, Marlan
dc.date.accessioned2020-11-04T19:18:48Z
dc.date.available2020-11-04T19:18:48Z
dc.date.issued2020-09-24
dc.description.abstractLateral flow assay (LFA) has long been used as a biomarker detection technique. It has advantages such as low cost, rapid readout, portability, and ease of use. However, its qualitative readout process and lack of sensitivity are limiting factors. We report a photon-counting approach to accurately quantify LFAs while enhancing sensitivity. In particular, we demonstrate that the density of SARS-CoV-2 antibodies can be quantified and measured with an enhanced sensitivity using this simple laser optical analysis.en_US
dc.description.sponsorshipWe would like to express our deep appreciation to TAMUS chancellor John Sharp, without whom this project would not have happened. We thank the Air Force Office of Scientific Research (Award No. FA9550–18-1–0141), Office of Naval Research (Award No. N00014-16-1-3054), National Science Foundation (Award Nos.1828416 and 1609608), Chancellor’s Research Initiative/Governor’s University Research Initiative (CRI/GURI), Robert A. Welch Foundation (Grant Nos. A-1261, A-1547, and A-1943), King Abdulaziz City for Science and Technology (KACST), and Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, Grant No. DFG-CRC1375NOA) for support of this work. X.L. was also supported by the Chinese Academy of Sciences (CAS). We also would like to thank B. Brick, K. Chamakura, P. Nordlander, J. Sharp, and R. Young for stimulating and helpful discussions.en_US
dc.description.urihttps://aip.scitation.org/doi/10.1063/5.0021842en_US
dc.format.extent5 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m24c8z-rtkh
dc.identifier.citationTao Peng et al., Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2, Appl. Phys. Lett. 117, 120601 (2020); https://doi.org/10.1063/5.0021842en_US
dc.identifier.urihttps://doi.org/10.1063/5.0021842
dc.identifier.urihttp://hdl.handle.net/11603/20019
dc.language.isoen_USen_US
dc.publisherAIPen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Physics Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsThis article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Tao Peng et al., Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2, Appl. Phys. Lett. 117, 120601 (2020); https://doi.org/10.1063/5.0021842 and may be found at https://aip.scitation.org/doi/10.1063/5.0021842.
dc.rightsAccess to this item will begin on 09/24/2021
dc.titleEnhancing sensitivity of lateral flow assay with application to SARS-CoV-2en_US
dc.typeTexten_US

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