Carbocyclic 5′-nor “reverse” fleximers. Design, synthesis, and preliminary biological activity

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dc.contributor.authorZimmermann, Sarah Catherine
dc.contributor.authorSadler, Joshua M.
dc.contributor.authorAndrei, Graciela
dc.contributor.authorSnoeck, Robert
dc.contributor.authorBalzarini, Jan
dc.contributor.authorSeley-Radtke, Katherine
dc.date.accessioned2025-07-30T19:22:47Z
dc.date.issued2011-05-19
dc.description.abstractA series of 5′-nor carbocyclic “reverse” flexible nucleosides or “fleximers” have been designed wherein the nucleobase scaffold resembles a “split” purine as well as a substituted pyrimidine. This modification was employed to explore recognition by both purine and pyrimidine metabolizing enzymes. The synthesis of the carbocyclic fleximers and the results of their preliminary biological screening are described herein.
dc.description.sponsorshipThe authors are grateful to Mrs Leentje Persoons, Mrs Frieda De Meyer, Mrs Leen Ingels, Mrs Lies Van den Heurck, Mrs Anita Camps and Mr Steven Carmans for excellent technical assistance. This project was supported by the National Institutes of Health Biomedical Research CBI Training grant T32GM066706 (KSR and SCZ). The antiviral assays were supported by a grant to K.U.Leuven (GOA no. 10/014).
dc.description.urihttps://pubs.rsc.org/en/content/articlelanding/2011/md/c1md00094b
dc.format.extent11 pages
dc.genrejournal articles
dc.genrepostprints
dc.identifierdoi:10.13016/m2timd-mgax
dc.identifier.citationZimmermann, Sarah C., Joshua M. Sadler, Graciela Andrei, Robert Snoeck, Jan Balzarini, and Katherine L. Seley-Radtke. “Carbocyclic 5′-nor ‘Reverse’ Fleximers. Design, Synthesis, and Preliminary Biological Activity.” MedChemComm 2, no. 7 (July 5, 2011): 650–54. https://doi.org/10.1039/C1MD00094B.
dc.identifier.urihttps://doi.org/10.1039/C1MD00094B
dc.identifier.urihttp://hdl.handle.net/11603/39600
dc.language.isoen_US
dc.publisherRoyal Society of Chemistry
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.relation.ispartofUMBC Student Collection
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Medicinal Chemistry copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1039/C1MD00094B.
dc.titleCarbocyclic 5′-nor “reverse” fleximers. Design, synthesis, and preliminary biological activity
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-0154-3459

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