Carbocyclic 5′-nor “reverse” fleximers. Design, synthesis, and preliminary biological activity

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nihms484381.pdf (1.18 MB)
 c1md00094b.pdf (1.21 MB)

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https://pubs.rsc.org/en/content/articlelanding/2011/md/c1md00094b

Permanent Link

https://doi.org/10.1039/C1MD00094B
 http://hdl.handle.net/11603/39600

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UMBC Chemistry & Biochemistry Department
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Author/Creator

Author/Creator ORCID

https://orcid.org/0000-0002-0154-3459

Date

2011-05-19

Type of Work

journal articles
postprints
Text

Department

Program

Citation of Original Publication

Zimmermann, Sarah C., Joshua M. Sadler, Graciela Andrei, Robert Snoeck, Jan Balzarini, and Katherine L. Seley-Radtke. “Carbocyclic 5′-nor ‘Reverse’ Fleximers. Design, Synthesis, and Preliminary Biological Activity.” MedChemComm 2, no. 7 (July 5, 2011): 650–54. https://doi.org/10.1039/C1MD00094B.

Rights

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Medicinal Chemistry copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1039/C1MD00094B.

Subjects

Abstract

A series of 5′-nor carbocyclic “reverse” flexible nucleosides or “fleximers” have been designed wherein the nucleobase scaffold resembles a “split” purine as well as a substituted pyrimidine. This modification was employed to explore recognition by both purine and pyrimidine metabolizing enzymes. The synthesis of the carbocyclic fleximers and the results of their preliminary biological screening are described herein.