A Simple Model for the Degradation of Cross-Sectional Area of a Skeletal Muscle Fiber Due to the Transcription Factor FOXO-1
| dc.contributor.advisor | Peercy, Bradford | |
| dc.contributor.author | Deal, BreAsia Niclole | |
| dc.contributor.department | Mathematics and Statistics | |
| dc.contributor.program | Mathematics, Applied | |
| dc.date.accessioned | 2021-01-29T18:13:40Z | |
| dc.date.available | 2021-01-29T18:13:40Z | |
| dc.date.issued | 2018-01-01 | |
| dc.description.abstract | We are investigating, through mathematical modeling and analysis, the signaling pathway of the FOXO-1 protein family transcription factors that involve the activation by Insulin Growth Factors (IGF) and Protein Kinase B (Akt). In doing so, it is important to know how the phosphorylation state of the FOXO-1 proteins causes the degeneration of muscular-skeletal fibers \cite{Wimmer}. In this paper, we will be modeling biochemical behaviors involving the FOXO-1 protein family and its effects in muscle atrophy. In studying muscle atrophy we consider how the nuclear to cytoplasm FOXO-1 ratio, the total FOXO-1, and the nuclear FOXO-1 effect the amount of degradation protein produced by FOXO-1 to breakdown the muscle volume, and the cross-sectional area of the muscle over the course of several days. | |
| dc.format | application:pdf | |
| dc.genre | theses | |
| dc.identifier | doi:10.13016/m29xkf-fofb | |
| dc.identifier.other | 11949 | |
| dc.identifier.uri | http://hdl.handle.net/11603/20888 | |
| dc.language | en | |
| dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
| dc.relation.ispartof | UMBC Mathematics and Statistics Department Collection | |
| dc.relation.ispartof | UMBC Theses and Dissertations Collection | |
| dc.relation.ispartof | UMBC Graduate School Collection | |
| dc.relation.ispartof | UMBC Student Collection | |
| dc.source | Original File Name: Deal_umbc_0434M_11949.pdf | |
| dc.title | A Simple Model for the Degradation of Cross-Sectional Area of a Skeletal Muscle Fiber Due to the Transcription Factor FOXO-1 | |
| dc.type | Text | |
| dcterms.accessRights | Distribution Rights granted to UMBC by the author. | |
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