Mechanoregulation of T-cell Function through Yap

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dc.contributor.authorCheng, Nan
dc.contributor.authorStampouloglou, Eleni
dc.contributor.authorSzeto, Gregory L.
dc.contributor.authorVarelas, Xaralabos
dc.date.accessioned2020-11-19T18:25:51Z
dc.date.available2020-11-19T18:25:51Z
dc.description.abstractAlthough tumor immunotherapy has been developed for various cancers, sustaining T-cell activation and recruitment in immunosuppressive solid tumors remains a major hurdle. T-cell function is modulated by mechanical cues, such as extracellular matrix (ECM) stiffness, but the molecular details by which such signals direct T-cell function are poorly understood. In this study, we investigate the role of Yap, a key mechanotransduction effector, in T-cell function in response to matrix stiffness. We aim to gain a better understanding of mechanoregulation on T-cell function through Yap, which will offer insights for the development of immunotherapies with improved T-cell response.en_US
dc.description.urihttps://www.bu.edu/mechanobiology/files/2020/10/N.-Cheng_CMTM-symposium-poster.pdfen_US
dc.format.extent1 pageen_US
dc.genrepostersen_US
dc.identifierdoi:10.13016/m2fz61-bks9
dc.identifier.citationNan Cheng, , Eleni Stampouloglou, Gregory L. Szeto and Xaralabos Varelas, Mechanoregulation of T-cell Function through Yap, https://www.bu.edu/mechanobiology/files/2020/10/N.-Cheng_CMTM-symposium-poster.pdfen_US
dc.identifier.urihttp://hdl.handle.net/11603/20097
dc.language.isoen_USen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectUMBC Translational Center for Age-Related Disease and Disparitiesen_US
dc.titleMechanoregulation of T-cell Function through Yapen_US
dc.typeTexten_US

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