Sociodemographic disparities in corticolimbic structures

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dc.contributorBoylan, Jennifer Morozink
dc.contributor.authorShaked, Danielle
dc.contributor.authorMillman, Zachary B.
dc.contributor.authorBeatty Moody, Danielle L.
dc.contributor.authorRosenberger, William F.
dc.contributor.authorShao, Hui
dc.contributor.authorKatzel, Leslie I.
dc.contributor.authorDavatzikos, Christos
dc.contributor.authorGullapalli, Rao P.
dc.contributor.authorSeliger, Stephen L.
dc.contributor.authorErus, Guray
dc.contributor.authorEvans, Michele K.
dc.contributor.authorZonderman, Alan B.
dc.contributor.authorWaldstein, Shari R.
dc.date.accessioned2019-09-26T14:03:05Z
dc.date.available2019-09-26T14:03:05Z
dc.date.issued2019-05-09
dc.description.abstractThis study sought to examine the interactive relations of socioeconomic status and race to corticolimbic regions that may play a key role in translating stress to the poor health outcomes overrepresented among those of lower socioeconomic status and African American race. Participants were 200 community-dwelling, self-identified African American and White adults from the Healthy Aging in Neighborhoods of Diversity across the Life Span SCAN study. Brain volumes were derived using T1-weighted MP-RAGE images. Socioeconomic status by race interactions were observed for right medial prefrontal cortex (B = .26, p = .014), left medial prefrontal cortex (B = .26, p = .017), left orbital prefrontal cortex (B = .22, p = .037), and left anterior cingulate cortex (B = .27, p = .018), wherein higher socioeconomic status Whites had greater volumes than all other groups. Additionally, higher versus lower socioeconomic status persons had greater right and left hippocampal (B = -.15, p = .030; B = -.19, p = .004, respectively) and amygdalar (B = -.17, p = .015; B = -.21; p = .002, respectively) volumes. Whites had greater right and left hippocampal (B = -.17, p = .012; B = -.20, p = .003, respectively), right orbital prefrontal cortex (B = -.34, p < 0.001), and right anterior cingulate cortex (B = -.18, p = 0.011) volumes than African Americans. Among many factors, the higher levels of lifetime chronic stress associated with lower socioeconomic status and African American race may adversely affect corticolimbic circuitry. These relations may help explain race- and socioeconomic status-related disparities in adverse health outcomesen_US
dc.description.sponsorshipThis work was supported by the National Institutes of Health (www.nih.gov), R01-AG034161 to S.R.W, ZIA–AG000513 to M.K.E. and A.B.Z., and The University of Maryland Claude D. Pepper Older Americans Independence Center (NIH grant P30 AG028747). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.description.urihttps://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0216338en_US
dc.format.extent21 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2a1q7-m5kp
dc.identifier.citationShaked D, Millman ZB, Moody DLB, Rosenberger WF, Shao H, Katzel LI, et al. (2019) Sociodemographic disparities in corticolimbic structures. PLoS ONE 14(5): e0216338. https://doi. org/10.1371/journal.pone.0216338en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0216338
dc.identifier.urihttp://hdl.handle.net/11603/14601
dc.language.isoen_USen_US
dc.publisherPLOSen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Psychology Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsCC0 1.0 Universal (CC0 1.0) Public Domain Dedication*
dc.rights.urihttps://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectsocioeconomic statusen_US
dc.subjectcorticolimbic regionsen_US
dc.subjectanterior cingulate cortex (ACC)en_US
dc.subjectprefrontal cortex (PFC)en_US
dc.titleSociodemographic disparities in corticolimbic structuresen_US
dc.typeTexten_US

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