Simultaneous Multicolor Imaging of Lymph Node Chains Using Hydroporphyrin-Doped Near-Infrared-Emitting Polymer Dots

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https://www.tandfonline.com/doi/full/10.2217/nnm-2023-0044

Permanent Link

https://doi.org/10.2217/nnm-2023-0044
 http://hdl.handle.net/11603/38633

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UMBC Chemistry & Biochemistry Department
UMBC Faculty Collection
UMBC Student Collection

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Author/Creator ORCID

https://orcid.org/0000-0001-6468-6900
 https://orcid.org/0000-0001-6098-3932
 https://orcid.org/0000-0003-2353-2459

Date

2023-04-01

Type of Work

journal articles
Text

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Citation of Original Publication

Rights

This work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
Public Domain

Subjects

fluorescence image
hydroporphyrin
quantum dot
lymphangiography
lymph node

Abstract

Aim: Evaluation of lymphatic drainage can be challenging to differentiate between separate drainage basins because only one ‘color’ is typically employed in sentinel node studies. This study aimed to test the feasibility of multicolor in vivo lymphangiography using newly developed organic polymer dots. Materials & methods: Biocompatible, purely organic, hydroporphyrin-doped near-infrared-emitting polymer dots were developed and evaluated for in vivo multicolor imaging in mouse lymph nodes. Results & conclusion: The authors demonstrated successful multicolor in vivo fluorescence lymphangiography using polymer dots, each tuned to a different emission spectrum. This allows minimally invasive visualization of at least four separate lymphatic drainage basins using fluorescent nanoparticles, which have the potential for clinical translation.