Simultaneous Multicolor Imaging of Lymph Node Chains Using Hydroporphyrin-Doped Near-Infrared-Emitting Polymer Dots

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dc.contributor.authorKato, Takuya
dc.contributor.authorRiahin, Connor
dc.contributor.authorFurusawa, Aki
dc.contributor.authorFukushima, Hiroshi
dc.contributor.authorWakiyama, Hiroaki
dc.contributor.authorOkuyama, Shuhei
dc.contributor.authorTakao, Seiichiro
dc.contributor.authorChoyke, Peter L.
dc.contributor.authorPtaszek, Marcin
dc.contributor.authorRosenzweig, Zeev
dc.contributor.authorKobayashi, Hisataka
dc.date.accessioned2025-06-05T14:02:58Z
dc.date.available2025-06-05T14:02:58Z
dc.date.issued2023-04-01
dc.description.abstractAim: Evaluation of lymphatic drainage can be challenging to differentiate between separate drainage basins because only one ‘color’ is typically employed in sentinel node studies. This study aimed to test the feasibility of multicolor in vivo lymphangiography using newly developed organic polymer dots. Materials & methods: Biocompatible, purely organic, hydroporphyrin-doped near-infrared-emitting polymer dots were developed and evaluated for in vivo multicolor imaging in mouse lymph nodes. Results & conclusion: The authors demonstrated successful multicolor in vivo fluorescence lymphangiography using polymer dots, each tuned to a different emission spectrum. This allows minimally invasive visualization of at least four separate lymphatic drainage basins using fluorescent nanoparticles, which have the potential for clinical translation.
dc.description.sponsorshipThis work was supported by the Intramural Research Program of the National Institutes of Health National Cancer Institute Center for Cancer Research ZIA BC 011513 a US Department of Energy Basic Energy Research DOE BER research grant DE SC0020346 to Z Rosenzweig and M Ptaszek and the UMBC Technology Catalyst Fund to M Ptaszek and Z Rosenzweig CR doctoral research is partially supported by NIH Chemistry Biology Interface CBI training grant NIH NIGMS T32 GM066706 The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed
dc.description.urihttps://www.tandfonline.com/doi/full/10.2217/nnm-2023-0044
dc.format.extent8 pages
dc.genrejournal articles
dc.identifierdoi:10.13016/m287ah-lkum
dc.identifier.urihttps://doi.org/10.2217/nnm-2023-0044
dc.identifier.urihttp://hdl.handle.net/11603/38633
dc.language.isoen_US
dc.publisherTaylor & Francis
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
dc.rightsPublic Domain
dc.rights.urihttps://creativecommons.org/publicdomain/mark/1.0/
dc.subjectfluorescence image
dc.subjecthydroporphyrin
dc.subjectquantum dot
dc.subjectlymphangiography
dc.subjectlymph node
dc.titleSimultaneous Multicolor Imaging of Lymph Node Chains Using Hydroporphyrin-Doped Near-Infrared-Emitting Polymer Dots
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0001-6468-6900
dcterms.creatorhttps://orcid.org/0000-0001-6098-3932
dcterms.creatorhttps://orcid.org/0000-0003-2353-2459

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