Spontaneous Calcium Release in Cardiac Myocytes: Store Overload and Electrical Dynamics

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dc.contributor.authorAlexander, Amanda M.
dc.contributor.authorDeNardo, Erin K.
dc.contributor.authorFrazier III, Eric
dc.contributor.authorMcCauley, Michael
dc.contributor.authorRojina, Nicholas
dc.contributor.authorCoulibaly, Zana
dc.contributor.authorPeercy, Bradford E.
dc.contributor.authorIzu, Leighton T.
dc.date.accessioned2018-09-25T19:38:29Z
dc.date.available2018-09-25T19:38:29Z
dc.date.issued2015
dc.description.abstractHeart disease is the leading cause of mortality in the United States. One cause of heart arrhythmia is calcium (Ca²⁺) mishandling in cardiac muscle cells. We adapt Izu's et al. mathematical reaction-diffusion model of calcium in cardiac muscle cells, or cardiomyocytes, [14], implemented by Gobbert [12], and analyzed in Coulibaly et al. [8] to include calcium being released from the sarcoplasmic reticulum (SR), the effects of buffers in the SR, particularly calsequestrin, and the effects of Ca²⁺ influx due to voltage across the cell membrane. Based on simulations of the model implemented in parallel using MPI, our findings aligned with known biological models and principles, giving us a thorough understanding of several factors that influence Ca²⁺ dynamics in cardiac myocytes. Speci cally, dynamic calcium store will cap previous calcium blow-up seen in the model. Calcium channels located in spatial opposition of calcium release units produce more predictable intracellular calcium propagation. And we used multi-parametric calcium dynamics tables, which act as a multidimensional bifurcation diagram, to visualize parameter boundaries between different biophysical dynamics.en_US
dc.description.sponsorshipThese results were obtained as part of the REU Site: Interdisciplinary Program in High Performance Computing (hpcreu.umbc.edu) in the Department of Mathematics and Statistics at the University of Maryland, Baltimore County (UMBC) in Summer 2015. This program is funded by the National Science Foundation (NSF), the National Security Agency (NSA), and the Department of Defense (DOD), with additional support from UMBC, the Department of Mathematics and Statistics, the Center for Interdisciplinary Research and Consulting (CIRC), and the UMBC High Performance Computing Facility (HPCF). HPCF is supported by the U.S. National Science Foundation through the MRI program (grant nos. CNS{0821258 and CNS{1228778) and the SCREMS program (grant no. DMS{0821311), with additional substantial support from UMBC. Co-author Michael Mc-Cauley was supported, in part, by the UMBC National Security Agency (NSA) Scholars Program through a contract with the NSA. Graduate assistant Zana Coulibaly was supported during Summer 2015 by UMBC.en_US
dc.description.urihttps://ir.library.illinoisstate.edu/spora/vol1/iss1/6/en_US
dc.format.extent15 pagesen_US
dc.genreundergraduate journal articleen_US
dc.identifierdoi:10.13016/M2M61BT31
dc.identifier.citationAlexander, Amanda M.; DeNardo, Erin K.; Frazier, Eric III; McCauley, Michael; Rojina, Nicholas; Coulibaly, Zana; Peercy, Bradford E.; and Izu, Leighton T. (2015) "Spontaneous Calcium Release in Cardiac Myocytes: Store Overload and Electrical Dynamics," Spora: A Journal of Biomathematics: Vol. 1: Iss.1, . DOI: https://doi.org/10.30707/SPORA1.1Alexanderen_US
dc.identifier.uriDOI: https://doi.org/10.30707/SPORA1.1Alexander
dc.identifier.urihttp://hdl.handle.net/11603/11378
dc.language.isoen_USen_US
dc.publisherIllinois State Universityen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Mathematics Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectdifferential equationsen_US
dc.subjectbiologyen_US
dc.subjectmathematical modelsen_US
dc.subjectUMBC High Performance Computing Facility (HPCF)en_US
dc.titleSpontaneous Calcium Release in Cardiac Myocytes: Store Overload and Electrical Dynamicsen_US
dc.typeTexten_US

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