Carbocyclic Thymidine Analogues for Use as Potential Therapeutic Agents

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dc.contributor.authorSeley-Radtke, Katherine
dc.contributor.authorSunkara, Naresh Kumar
dc.date.accessioned2025-07-30T19:22:49Z
dc.date.issued2009-07-29
dc.description.abstractThe discovery of azidothymidine's (AZT) activity against human immunodeficiency virus (HIV) provided strong rationale for the design of additional thymidine analogues. One drawback of many nucleoside analogues is the toxicity that often arises due to phosphorylation by cellular kinases. In order to overcome this problem, a number of truncated nucleosides lacking the 4′-hydroxymethyl group have been synthesized. In that regard, the synthesis and preliminary biological results for two truncated carbocyclic thymidine analogues are presented herein.
dc.description.sponsorshipThis work was supported by the National Institutes of Health (RO1 CA97634, KSR). The authors also want to thank Dr. Sunny Zhou of Northeastern University for performing the SAHase assays.
dc.description.urihttps://www.tandfonline.com/doi/full/10.1080/15257770903091920
dc.format.extent10 pages
dc.genrejournal articles
dc.genrepostprints
dc.identifierdoi:10.13016/m2fkfc-5aaw
dc.identifier.citationSeley-Radtke, Katherine L., and Naresh K. Sunkara. “Carbocyclic Thymidine Analogues for Use as Potential Therapeutic Agents.” Nucleosides, Nucleotides & Nucleic Acids 28, no. 5–7 (August 11, 2009): 633–41. https://doi.org/10.1080/15257770903091920.
dc.identifier.urihttps://doi.org/10.1080/15257770903091920
dc.identifier.urihttp://hdl.handle.net/11603/39603
dc.language.isoen_US
dc.publisherTaylor & Francis
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.relation.ispartofUMBC Student Collection
dc.rightsThis is an Accepted Manuscript of an article published by Taylor & Francis in Nucleosides, Nucleotides & Nucleic Acids on 2009-07-29, available online: https://www.tandfonline.com/doi/full/10.1080/15257770903091920.
dc.subjectpyrimidine
dc.subjectCarbocyclic
dc.subjectSAHase
dc.subjectnucleosides
dc.subjectneplanocin
dc.subjectaristeromycin
dc.titleCarbocyclic Thymidine Analogues for Use as Potential Therapeutic Agents
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-0154-3459

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