Carbocyclic Thymidine Analogues for Use as Potential Therapeutic Agents
Author/Creator
Author/Creator ORCID
Date
Type of Work
Department
Program
Citation of Original Publication
Seley-Radtke, Katherine L., and Naresh K. Sunkara. “Carbocyclic Thymidine Analogues for Use as Potential Therapeutic Agents.” Nucleosides, Nucleotides & Nucleic Acids 28, no. 5–7 (August 11, 2009): 633–41. https://doi.org/10.1080/15257770903091920.
Rights
This is an Accepted Manuscript of an article published by Taylor & Francis in Nucleosides, Nucleotides & Nucleic Acids on 2009-07-29, available online: https://www.tandfonline.com/doi/full/10.1080/15257770903091920.
Abstract
The discovery of azidothymidine's (AZT) activity against human immunodeficiency virus (HIV) provided strong rationale for the design of additional thymidine analogues. One drawback of many nucleoside analogues is the toxicity that often arises due to phosphorylation by cellular kinases. In order to overcome this problem, a number of truncated nucleosides lacking the 4′-hydroxymethyl group have been synthesized. In that regard, the synthesis and preliminary biological results for two truncated carbocyclic thymidine analogues are presented herein.