Optimizing tPA Therapy for Stroke Victims

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dc.contributor.authorChatain, Oscar Louis Jean
dc.contributor.departmentChemistryen_US
dc.date.accessioned2020-02-28T19:35:27Z
dc.date.available2020-02-28T19:35:27Z
dc.date.issued2018
dc.description.abstractTissue Plasminogen Activator (tPA) remains one of the most effective thrombolytic agents given to patients that present with acute ischemic strokes. However, increased chances of brain hemorrhaging are observed if administered outside of the accepted time window of 4.5 hours. Patients who already have prior trauma comorbidities are at the highest risk and are therefore not eligible for reperfusion therapy using tPA. In this manuscript, the author aims to assess the feasibility of counteracting tPA mediated blood brain barrier (BBB) degradation and proposes novel diagnostic techniques to quantify the efficacy of potential adjuvant therapies reported in the literature.en_US
dc.format.extent27 pagesen_US
dc.genrethesesen_US
dc.identifierdoi:10.13016/m2czq4-0p4a
dc.identifier.urihttp://hdl.handle.net/11603/17441
dc.language.isoen_USen_US
dc.relation.isAvailableAtSalisbury Universityen_US
dc.subjectTransient ischemic attacken_US
dc.subjectClinical medicineen_US
dc.subjectTheraputicsen_US
dc.titleOptimizing tPA Therapy for Stroke Victimsen_US
dc.typeTexten_US

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