EVALUATING THE ROLE OF EXOSOMES FROM SIVMAC239X INFECTED CELLS ON VIRUS TRANSMISSION IN VIVO
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Hood College Biology
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Biomedical and Environmental Science
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Abstract
This project aims to determine the number of virus particles transmitted to non-human
primates after intra-rectal challenge. The virus, SIVmac239X, is a transfection derived stock
containing ten molecularly tagged variants which are functionally equivalent but genetically
distinct. Challenge stocks will be created following exposure to virus-free exosomes isolated
from various infected cell types including monocyte derived macrophages which are a primary
target of SIV.