Modeling Space Radiation Induced Cognitive Dysfunction Using Targeted And Non-Targeted Effects

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dc.contributor.authorShuryak, Igor
dc.contributor.authorBrenner, David
dc.contributor.authorBlattnig, Steven
dc.contributor.authorShukitt-Hale, Barbara
dc.contributor.authorRabin, Bernard
dc.date.accessioned2021-01-04T20:26:11Z
dc.date.available2021-01-04T20:26:11Z
dc.date.issued2020-12-01
dc.descriptionThis work was supported by the National Aeronautics and Space Administration (NASA) grant NNX16AR81A to DJB and NASA Grant NNX16AE06G to BMR and BSH.en_US
dc.description.abstractRadiation-induced cognitive dysfunction is increasingly recognized as an important risk for human exploration of distant planets. Mechanistically-motivated mathematical modeling helps to interpret and quantify this phenomenon. Here we considered two general mechanisms of ionizing radiation-induced damage: targeted effects (TE), caused by traversal of cells by ionizing tracks, and non-targeted effects (NTE), caused by responses of other cells to signals released by traversed cells. We compared the performances of 18 dose response model variants based on these concepts, fitted by robust nonlinear regression to a large published data set on novel object recognition testing in rats exposed to multiple space-relevant radiation types (H, C, O, Si, Ti and Fe ions), covering wide ranges of linear energy transfer (LET) (0.22-181 keV/µm) and dose (0.001-2 Gy). The strongest support (by Akaike information criterion) was found for an NTE+TE model where NTE saturate at low doses (~0.01 Gy) and occur at all tested LETs, whereas TE depend on dose linearly with a slope that increases with LET. The importance of NTE was also found by additional analyses of the data using quantile regression and random forests. These results suggest that NTE-based radiation effects on brain function are potentially important for astronaut health and for space mission risk assessments.en_US
dc.description.urihttps://www.researchsquare.com/article/rs-114592/v1en_US
dc.format.extent14 pagesen_US
dc.genrereports preprintsen_US
dc.identifierdoi:10.13016/m2o2rs-udut
dc.identifier.citationShuryak, Igor; Brenner, David; Blattnig, Steven; Shukitt-Hale, Barbara; Rabin, Bernard; Modeling Space Radiation Induced Cognitive Dysfunction Using Targeted And Non-Targeted Effects; Scientific Reports (2020); https://www.researchsquare.com/article/rs-114592/v1en_US
dc.identifier.urihttps://doi.org/10.21203/rs.3.rs-114592/v1
dc.identifier.urihttp://hdl.handle.net/11603/20276
dc.language.isoen_USen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Psychology Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsPublic Domain Mark 1.0*
dc.rightsThis work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
dc.rights.urihttp://creativecommons.org/publicdomain/mark/1.0/*
dc.titleModeling Space Radiation Induced Cognitive Dysfunction Using Targeted And Non-Targeted Effectsen_US
dc.typeTexten_US

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